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Sentinel Modular Program for Propensity Score“Matched Cohort AnalysesHennessy

Posted on October 5, 2022 By
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Hello my name is mei-chiao chiu at university of pennsylvania and presenting our work sentinel modular program for propensity score matching cohort analysis application to grab you write creepy side and series hypoglycemia this work was conducted by a group of us at university of pennsylvania the united states food and drug administration university of iowa the

Program and women’s hospital and the sentinel operations center at harvard medical school and have a program healthcare institute sentinel is a program sponsored by the united states food and drug administration to monitor the safety of medical products it utilizes a distributed data system in which data partner sites maintained and regularly update patients

Administrative claims and clinical information formatted in a common data model a customizable set of pre-tested modular programs compatible with the common data model enables the food and drug administration to perform analysis evaluating associations between medical products and pre specified house outcomes the sentinel propensity score matching tool is one

Of these customizable sentinel modular programs and enables the conduct of cohort analysis that are matched on propensity scores prior epidemiologic studies reported a 1.67 21.9 fold increased risk of serious hypoglycemia associated with grab your id versus crappy diet and the systematic review of clinical trials found a higher risk for grab your id compared to

Other insolence of wilcock including glipizide the objective of our study was to evaluate the ability of the sentinel propensity score matching tool to reproduce the increased risk of serious hypoglycemia singing users of grab your id versus group reside expedient fashion we conducted surrey propensity score matching color analysis using propensity scores that

Included predefined co virus only cover is identified by the automated high dimensional propensity score algorithm and both predefined coverage and those selected by the high dimensional propensity score we submitted our query to the sentinel operation center the pre-tested computer program was then distributed to data partners each data partner run the query

Against their local data estimated the propensity scores and matched patients based on the propensity score then data partners returned results to the sentinel operations center we are secure network portal that included the propensity scores indicators for exposure and outcome and follow-up days the results were aggregated at the sentinel operations center and

Sent to the food and drug administration team we found that england alice’s match are three different types of propensity scores the instance rate of series hypoglycemia was one point three six to one point five one fold higher in users of grab your id versus clippy’s id these findings are consistent with the results of prior studies and demonstrated the ability

Of the sentinel propensity score matching tool to reproduce this no association in sentinel our study is subject to limitations related to the nature of our data because our reliance on icd-9 diagnostic codes can result in the under s detainment of coverage we cannot exclude the possibility of residual confounding to a certain outcomes we used validated algorithms

With high positive predictive values this study supports the utility of sentinel to actively exam the safety of medical products

Transcribed from video
Sentinel Modular Program for Propensity Score–Matched Cohort AnalysesHennessy By Epidemiology

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