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Atenolol wikipedia article audio atenolol is a selective beta one receptor antagonist a drug belonging to the group of beta blockers a class of drugs used primarily in cardiovascular diseases introduced in 1976 atenolol was developed as a replacement for propranolol in the treatment of hypertension it works by slowing down the heart and reducing its workload unlike
Propranolol atenolol does not readily pass through the blood-brain barrier thus decreasing the incidence of central nervous system side-effects atenolol is one of the most widely used beta blockers in the united kingdom and was once the first-line treatment for hypertension atenolol is effective at reducing blood pressure but recent studies indicate that it does not
Reduce the morbidity or mortality caused by hypertension and may even increase mortality in some subgroups this means that when people take this drug they get better blood pressure numbers but they still die of heart attacks and strokes despite the lower blood pressure medical uses side effects in addition the role for beta-blockers in general and hypertension was
Downgraded in june 2006 in the united kingdom and later in the united states as they are less appropriate than newer blood-pressure medications including calcium channel blockers thiazide diuretics angiotensin converting enzyme inhibitors and angiotensin receptor blockers particularly in the elderly atenolol is used for a number of conditions including hypertension
Angina long qt syndrome acute myocardial infarction super ventricular tachycardia ventricular tachycardia and the symptoms of alcohol withdrawal off-label uses of atenolol as with other cardio selective beta blockers include symptomatic treatment of psychological issues such as anxiety beta blockers are effective for some in treating the somatic effects of anxiety
In these instances dosing is used as needed instead of regular daily dosing due to its hydrophilic properties the drug is less suitable in migraine prophylaxis compared to propranolol because for this indication atenolol would have to reach the brain in high concentrations which is not the case because atenolol does not pass through the blood-brain barrier atena
Law was the main beta-blocker identified as carrying a higher risk of provoking type 2 diabetes leading to its downgrading in the united kingdom in june 2006 to 4th line agent in the management of hypertension overdose anteye hyper therapy with atenolol provides weaker protective action against cardiovascular complications compared to other antihypertensive drugs in
Some cases diuretics are superior dition atenolol has been found to lack mortality benefits and even to increase mortality in older adults symptoms of overdose are due to excessive pharmacodynamic actions on beta 1 and also beta 2 receptors these include braddock ardea severe hypotension with shock acute heart failure hypoglycemia and bronco reactions treatment is
Largely symptomatic hospitalization and intensive monitoring is indicated activated charcoal is useful to absorb the drug atropine will counteract braddock rda glucagon helps with hypoglycemia dobutamine can be given against hypotension and the inhalation of a beta to memetic as hexa prenta line or salbutamol will terminate bronchospasms blood or plasma atenolol
Concentrations may be measured to confirm a diagnosis of poisoning in hospitalized patients or to assist in a medical legal death investigation plasma levels are usually less than 3 mg / l during therapeutic administration but can range from 330 mg / l in overdose victims society and culture atenolol has been given as an example of how slow healthcare providers
Are to change their prescribing practices in the face of medical evidence that indicates that a drug is ineffective in 2012 thirty three point eight million prescriptions were written to american patients for this drug in 2014 it was in the top 1% of drugs prescribed to medicare patients although the number of prescriptions has been declining steadily since the
Evidence against its efficacy was published it has been estimated that it would take 20 years for doctors to stop prescribing it for hypertension
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