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Why use telmisartan in bodybuilding? welcome to j3 university, your source for physique enhancement education. question i got was why are people using telmisartan in the enhanced physique competitor arena in bodybuilding and in general i wanted to suggest like why are people using just arbs in general which telmisartan
Is an arb which is an angiotensin renin blocker so it’s blocking would they use this within bodybuilding and pd’s in general more anabolic interesting the problems arise with using these compounds is that they do increase the renin angiotensin aldosterone system and so this is released the liver and is
Converted to angiotensin one the lungs convert to angiotensin ii angiotensin ii has some sites around the body that it works to cause it to hold more water sodium the adrenal glands to increase aldosterone output which further increases sodium retention also for the pituitary gland to release antidiuretic
Hormone which causes water reabsorption so all this process is really important to regulate blood volume and blood pressure if it was to drop to low but you could see that this could be problematic you have an over activation of this system we’re going to abbreviate and call it ross so i’m not always saying written in
Angiotensin aldosterone is when a lot of issues can arise for one with higher levels of ross activity you would guess that you’d have greater water retention this is a lot of times what you’re seeing with taking high dose of anabolics is increase in water retention a lot of times estrogen gets blamed but it can
Be a lot due to this system then also with that water retention you can have an increase in blood pressure so yes this system can helpfully regulate blood pressure but also it can really increase blood pressure as well now along with just those regulations this isn’t just about blood pressure although blood pressure
It puts more pressure on the for the heart and the kidneys and just the whole vascular system but angiotensin interleukin-6 tumor necrosis factor all these inflammatory cytokines can damage organ systems damage the kidney they go to the brain just think them systemically these inflammatory markers going
Around moving around the organ systems and causing tissue damage and inflammation this is why some of the leading issues with high doses of pd’s are in the heart the brain and the kidney part of it is being in this pro-inflammatory state and is usually a root cause to a lot of disease states that we’re seeing with
Insulin resistance cardiovascular disease alzheimer’s dementia the cognitive disorders and chronic and renal failure just blood pressure regulation with the system markers um also dystera use in general can cause an increase in reactive oxygen species so it causes more oxidative stress and again this
Stress can also impact organ function as well so with this system you’re having an increase in reactive oxygen species oxidative damage inflammatory markers and high blood pressure and we see this over activation of the raw system is very prevalent in cardiovascular disease which causing tissue remodeling in left
Ventricular hypertrophy cardiac dysfunction endothelial cell dysfunction so your blood vessels are also going much you can have a decrease in nitric oxide synthase too so you’re no longer having this this elasticity within your blood vessels common damage to the arteries and you have this inflammatory
State now causing more atherosclerosis and and so it’s just this this whole cascade of snowball kind of can occurs so what do we do about it well what do we address you’re taking high doses of pds this is a a major factor in all these issues that arise in this increase in ross what do you do well we have angiotensin
2 receptor blockers an arb and basically all the negative things i said they work to reverse that so we see a decrease in blood pressure decrease in water retention for one is is great just from a physique aspect i’ve used arbs to lower angiotensin too in turn lowers aldosterone and diuretic hormone people
Can retain less water via that means rather than using a diuretic we’re addressing even further back the the root issue here so there that that aesthetic reason also in off-season phases if you’re having a lot of water attention sometimes you can blur the lines between am i getting body fat am i gaining is this water
Is this muscle so it helps to make give a little bit of a clear picture of the type of progress you’re making inflammation lower oxidative stress all those are huge positives and so that within turn it also is going to be neuro protective for the brain it’s going to protect the heart the brain and
Atherosclerosis cardiac remodeling issue being left ventricular hypertrophy right in in ped users it’s a protective thing against this so all these rbs have this mechanism there’s telemassardon consideration of of you know with your doctor what might be something be in place telemazarin has been one that’s been more
Popular and i want about so much and there’s a few reasons why so and more so for ped users specifically one reason being it’s has a very long half-life of it does work on the p-par y pathway which has gene expressions in regard to carbohydrate and lipid metabolism so we’re going to see positive alterations
To increasing insulin sensitivity lower ldl rays hdl which are very pertinent to users and you can also have just a decrease in visceral body fat too with agar regard to that increase in beta oxidation fatty acid metabolism so you have this kind of this extra benefit that telomere brings about which we do see uh
As in bodybuilding what do you what is what’s happening partitioning towards visceral adipose tissue and then you can have a compound where you have a 24-hour protective roll versus some of the other require more frequent dosing so this is why telemazardan used in the enhanced competitor realm and this
Is a prophylactic strategy so it’s not something to be utilized once you’ve gotten issues to arise it’s to be put in place to prevent issues from occurring long term down the road so it’s something for consideration and something that would be utilized if you were to use it a couple questions that i had had gone from
It if you were had normal blood pressure would it lower your blood pressure more and no this is if you had an over activation of the rash system you’d have a lowering of angiotensin ii blocking those receptors and we’d have a normalization of blood pressure if your blood pressure was already normal it’s not going
To further lower it lower it why would i even take this then it’s because of of high blood pressure so even if you had normal blood pressure but you still had raises in aldosterone still presents risk for cardiovascular disease atherosclerosis just independent just of of blood pressure okay so just keep that a note
That there’s a yes it works on blood pressure we it provides in protect protective aspects so anyway that’s going to wrap up my question which is a long-winded question of course have another question you want me to answer it happy to hit it on our next q a from j3u
Transcribed from video
WHY TELMISARTAN IN BODYBUILDING? | John Jewett | J3 University By John Jewett
