Why is Clavulanic Acid, added to Amoxycillin Antibiotic??
Hello dear viewers welcome back to medkem companion channel today in this session we will discuss why clavolanic acd is added to the amoxicillin antibiotic while making a suitable dosage form you have seen several dosage form which is available in the market in which amoxicillin is usually present with clavolanic acid so in order to answer this question we first
Need to understand the structure of amoxicillin and the mechanism by which it kills the bacteria so first the structure of amoxicillin amoxicillin is a broad spectrum antibiotic it kills both gram positive and gram negative bacteria and it have penicillin like structure here this amoxicillin have beta electron ring this is a four membered cyclic nucleus which
Is fused with thiazolidine ring the anti-pectoral power of this amoxicillin resides in its beta electron ring so we can say that this beta electron ring is only or solely responsible for its antibacterial activity now how this amoxicillin kill the bacteria amoxicillin attack this bacteria with its beta electron ring and kills the bacteria so this beta electron
Ring directly involved in killing this bacteria what bacteria will do to preserve its own life so bacteria have developed another mechanism it secretes what a new enzyme which is known by the name beta electrons enzyme so this enzyme attack this amoxicillin beta electrum ring before it reaches to the bacteria so this enzyme continuously attacks this beta
Electron ring of several amoxicillin molecule and destroy this beta electron ring and thus this amoxicillin loses its antibacterial power now why we have added clavolanic acid so in order to preserve this amoxicillin or in order to safeguard this amoxicillin we have added clavulanic acid why because clavolanic acid also have beta electron ring in its structure
As it is present in the amoxicillin so bacteria so this enzyme falsely attacked this clavellanic acid beta electrum ring and as this enzyme attack this clavelanic acid this clavelanic acid inactivate this enzyme so all the enzyme which is secreted by this bacteria all the enzyme gets inactivated as it interact with the clavolanic acid and thus clowlanic acid
Sacrifices his own life to safeguard this amoxicillin molecule by the attack of this beta electromag enzyme that’s why he sacrifices this clausic acid sacrifices his own life that’s why this clavolanic acid is also known by the name suicidal substrate so clavolanic acid is added to the amoxicillin molecule as a suicidal substrate to safeguard this amoxicillin
By the attack of this enzyme and thus in this way the antiviral power of amoxicillin gets preserved and this amoxicillin now in spite of the presence of this enzyme i take this bacteria and kill this bacteria so this is how this whole mechanism works so that’s why we have seen several medicine which are available in the combination of amoxicillin along with claulani acid thank you
Transcribed from video
Why is Clavulanic Acid, added to Amoxycillin Antibiotic?? By MANSURI ACADEMY
