Vitamin D Magnesium and B12 – A Cohort Study from Singapore
Let’s review a study by researchers from singapore general hospital this study is about the clinical outcomes in older patients with coronavirus who received a combination of vitamin d magnesium and vitamin b12 compared with those who did not by the way we will refer to vitamin d magnesium and vitamin b12 as dnb throughout this video the researchers hypothesized
That fewer patients administered this combination would require oxygen therapy intensive care support or a combination of both compared to those who did not let’s talk about the method they used it’s worth noting that this was a retrospective cohort observational study of 43 consecutive patients hospitalized in singapore general hospital whose age was 50 years or
More and they were with covid19 in a tertiary academic hospital before april 6 2020 no patients received the dnb combination after this date patients were administered a thousand international units daily oral vitamin d3 150 milligram daily oral magnesium and 500 microgram daily oral vitamin b12 upon admission if they did not require oxygen therapy primary outcome
Was deterioration leading to any form of oxygen therapy intensive care support or both patients were follow-through either for 30 days from the onset of symptoms or the hospital discharge let’s see the results between january 15th and april 15th of 2020 the researchers identified 43 consecutive patients whose age was 50 years or more and were with covid19 17
Patients received dnb before onset of primary outcome and 26 patients did not dmb could continue for 14 days unless the patient recovered or became deteriorated to require oxygen intensive care support or both after adjusting for age or hypertension separately in a multivariate analysis the intervention group retained protective significance fewer treated patients
Than control patients required initiation of oxygen therapy during hospitalization 17.6 percent of dmb needed oxygen compared to 61.5 that did not receive dmv p-value is 0.006 which is significant dmv exposure was associated with odds ratio of 0.13 with a 95 confidence interval between 0.03 and 0.59 for oxygen therapy intensive care support or both on univariate
Analysis dmb exposure was associated with odds ratios of 0.20 with a 95 confidence interval between 0.04 to 0.93 for oxygen therapy intensive care support or both on multivariate analysis researchers suggest that their study supports further larger randomized controlled trials to ascertain the full benefit of this combination in ameliorating the severity of covet 19.
We recommend that you read the whole paper for an in-depth understanding of the results and limitations
Transcribed from video
Vitamin D, Magnesium, and B12 – Singapore Study By Drbeen Medical Lectures
