In this video we examine the evidence for small fiber neuropathy as a driver of fibromyalgia and other chronic pain disorders. We also look at a nutrient which can help to resolve the pain and restore nervous system function: Agmatine!!!
Is the pain in fibromyalgia actually caused by a form of neuropathy and does this mean that it can be treated using similar tools as one might use to address other forms of neuropathy hi there this is elliott from eon nutrition and in today’s video we’re going to be looking at how the pain caused in fibromyalgia is potentially a form of neuropathy called small
Fiber neuropathy at least in some people so this is pretty controversial because most people think of fibromyalgia as a rheumatic condition meaning mainly affecting the joints of the muscles however in this case at least in some people the the pain is probably stemming from the nervous system being the spinal cord the brain or even the peripheral nerves so in this
Video we’ll look at some of the basic mechanisms by which this happens and we’ll also focus on a particular nutrient called agmatine which has been shown to be very effective in this condition for those who are not aware small fiber neuropathy is a type of neuropathy which is associated with chronic pain of various kinds the symptoms include sensitivity to touch
Burning or stinging numbness and tingling or chronic eggs the condition can also produce systemic nervous system dysfunction and this can affect other organs and this may present as abnormal sweating poor bladder control gut dysfunction problems with the heart including arrhythmias palpitations and tachycardia common causes of this kind of neuropathy include
Diabetes autoimmune conditions attacking the nerves viral or bacterial infection alcoholism toxicity of pharmaceutical medications celiac disease vitamin b12 deficiency and isospect thymine deficiency also throughout the past decades there have been numerous studies showing evidence of small fiber neuropathy in patients with fibromyalgia some studies showed up
To 30 percent of people with fibro actually fit the diagnostic criteria for small fiber neuropathy one study using skin biopsy found that neuropathy was found in 41 of patients with fibromyalgia similarly complex regional pain syndrome and unexplained widespread pain also show evidence of this in contrast with the idea of fibromyalgia being a rheumatic condition
It’s more likely that the problem is actually stemming from dysfunction within the brain and spinal cord rather than the muscles or joints and taking a basic look at how pain is processed can provide some insight into why this might be the sensation of pain starts in the periphery with sensory information being detected by neurons and then sent to the spinal column
These signals are propagated to the brain where they are further processed if the information is not conveyed or processed in the correct way then chronic pain disorders including neuropathic pain can result the signals running through the spinal cord to the brain involve the release of an excitatory neurochemical called glutamate glutamate is activating nmda
Receptors on the surface of adjacent neurons and this message travels to very specific regions of the brain which are tasked with processing this information this constitutes pronociception or in other words pro pain signaling on the other hand signals coming from other regions of the brain act to oppose or counteract this this is through descending pathways which
Essentially inhibit pain this is essentially a counterbalance and is called antinocioception or anti-pain signaling one of the key areas involved in pain processing is called the dorsal root ganglia and this is located along the spinal cord dysfunctions of this kind of tissue is associated with small fiber neuropathy and has been implicated in fibromyalgia pain in
Various papers it’s been shown that after some kind of an initial triggering event maybe trauma some kind of an infection perhaps even a nutritional deficiency nerve cells within this region of the sprout spine can essentially branch out and grow through a process called sprouting interestingly sprouting results in the dorsal root ganglia becoming very sensitive
To sympathetic nervous system chemicals such as catecholamines ironically this results in excessive firing of neurons which is otherwise known as hyperexcitability now this concept is what is behind the idea of stress-induced pain in fibromyalgia it’s literally the case that activation of the sympathetic nervous system triggers the firing of sensory neurons this
Problem of excessive neuron firing which enhances ascending pathways associated with increased pain is unfortunately coupled with reduced or disrupted descending pathways which are responsible for the exact opposite dampening down the signal so in fibromyalgia you have a an enhancement of these propane signals going up to the brain and you have a reduction in the
Brain’s ability to dampen those signals so the result is chronic pain seemingly without any kind of genuine painful stimuli now if you want a more detailed look at this i have discussed this concept at length in the following article titled thymine fibromyalgia and chronic pain this can be found on my website which i’ve linked to below and in that article i discuss
The underlying mechanisms and causes of fibromyalgia and examine the evidence and rationale for using high doses of thymine otherwise known as vitamin b1 to address this condition however another extremely interesting molecule which has a lot of potential for addressing this condition is called agmatine agmatine is a polyamine derived from the dietary amino acid
Arginine in the cell arginine is converted into agmatine vitamin enzyme located in the mitochondria and agmatine is then used for a variety of purposes and is found naturally in the human body at all times anyway but it turns out this particular molecule has numerous neuroprotective qualities and is very important for the brain interestingly agmatine directly
Antagonizes or blocks the nmda receptors in the spinal cord and central nervous system agmatine also reduces the release of glutamate from neurons and furthermore agmatine can also activate the gaba-a receptors to exert a kind of inhibitory or calming effect on nervous tissue this diagram also shows some of the other mechanisms of action which includes the activation
Of other receptors which exert positive effects on things like cell survival and neuroplasticity there’s a surprisingly large body of research demonstrating significant benefits for small fiber neuropathy using agmatine and also other kinds of nerve driven pain radiculopathy spinal cord injury tactile allodinia reduction in nitric oxide which is associated with
Neurocytotoxicity and neuroinflammation agmatine has been shown to do a lot for the brain in fact this molecule shows of promise for a variety of different central nervous system conditions primarily through counteracting neuroinflammation oxidative stress and cell death this paper shows an interesting diagram listing some of the research on this molecule i highly
Recommend looking into it actually it’s for this reason that i’ve included agmatine in several of the protocols listed in the document i recently released this document includes direction on mega dosing thiamin and specific protocols for different conditions this includes fibromyalgia and chronic fatigue syndrome and i mentioned some of the other supplements
And nutrients which have research behind them and have been shown to be quite effective for this looking at dosing the average equivalent dose used in studies is anywhere between one thousand and two thousand milligram per day if one pairs this with other interventions which i’ve also discussed elsewhere and which have been found to be effective i think that one
Might see significant improvement in the fibromyalgia pain so to briefly summarize fibromyalgia has been associated with small fiber neuropathy and it’s possible that some of the people who have this condition the pain they experience is neuropathic or neurological in origin small fiber neuropathy and fibromyalgia alike seem to be associated with issues with an
Area of the spinal cord or a type of tissue in the spinal cord called the dorsal root ganglia here there is excessive firing of neurons where there’s a heightened release of a neurotransmitter called glutamate this activates nmda receptors and this heightens signals going to the brain to signal pain unfortunately in fibromyalgia there is also problems with the
Dampening signal for pain so we end up with a lack of a counterbalance effect someone has lots of information coming in to signal for pain and not enough control to dampen those signals and so we end up with chronic unresolved pain with seemingly no cause there are numerous things which can help with this i’ve done a lot of work into thymine’s role in high doses
And how this can be used to counteract the effects that we see in fibromyalgia and in neuropathy however another very interesting molecule is agmatine agmatine can directly counteract a lot of the biochemical changes which can occur in small fiber neuropathy and therefore has been shown to reduce pain quite significantly what i would say however is this may not
Necessarily be getting to the root cause though it can help with symptoms and while someone is trying to identify the root cause it can be very useful um until they find out what that actually is and how to deal with that to use something which can reduce the symptoms that they experience so thanks for tuning in i hope that you found this video helpful please like
And subscribe share on social media platforms with others who you might think might benefit thank you and see you next time
Transcribed from video
This Unknown Nutrient For Fibromyalgia, Chronic Pain & Neuropathy By EONutritionliveBroadcastDetails{isLiveNowfalsestartTimestamp2021-12-29T213609+0000endTimestamp2021-12-29T214901+0000}
