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Synthesis of Isosorbide Dinitrate

Posted on October 28, 2022 By
Health

Synthesis

Hello friends today’s topic is synthesis of isil’s or by tonight right now this is the structure for isis are white it belongs to the category of nt and jaian are with rocks now if you look at the structure you will find that there are two five membered rings containing oxygen joined with each other two oxygens are buried push a number two and five along with two

Nitro groups on oxygen the int c name of this compound is one from a for this 2 3 comma 6 die n hydro to 5 die old nitro deep blue sea tall now if we look at the synthesis new will easily find that why the name is given to it the synthesis of this compound start with 6 carbon alcohol that is the goose eat all well this is the two dimension of this structure for

The goose it all very will find that there are six carbons joined with each of the knot chain and containing six hydroxy groups the classical feature of this molecule is that it consists of the hydroxy group on one end fourth position on right hand side where is the hydroxy group on third and the sixth carbon on the left side to be to make more facilitate here is

The three-dimensional structure and this predominance of structure you will easily find that the hydroxy group on carbon number one and the hydroxyl group on carbon number four are close enough to each other to react and liberate a water molecule just making a five-member ring with oxygen likewise the hydroxy group on question number three and at position number

Six in closed environment they will react to form to liberate a second water molecule in this the second ring is generated so a water molecule is liberated from the reaction of carbon number one and four that’s why it is 1/4 and our second water molecule is generated between carbon number three and six so it is three six though two water molecules are released so

It is dye and hydro the two nitro groups are on the oxygen so it is to fight dying all nitro and though this structure is obtained from digital so that’s why dialect name is suffix with d to c tall so ultimately the starting material is d glue seat all it is here is the two-dimensional structure here is the three time it’s not a structure like this the d does it

React to it but at all with sulphonic a seat whereby the 1st and 4th hydroxyl group and the 3rd and the sixth hydroxyl groups are ready to release two water molecules the cyclization takes place this result in the formation of isis or bite here you can easily find that to a five membered oxygen containing ring and joined with each other having two hydroxyl groups

At position number two and at push number five when isis or might react with nitrating a seat at least the mixture of concentrated nitric acid and sulfuric acid liberate a nitronium ion which will fine which act as electrophile and will get attacked on the oxygen of the hydroxyl group to liberate the title molecule isis or by dye nitrate

Transcribed from video
Synthesis of Isosorbide Dinitrate By Josh_Tutorials

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