We’re going to talk about sulfonamides and trimethoprim otherwise known as sulfa antibiotics so that’s a specific class we’ll get started on that i don’t have very many slides for this alright so self and amides and trimethoprim you’re gonna see these together otherwise known as bactrim so it’s sulfa and trimethoprim put together but we’ll talk about what the sulfonamide
Does in the trimethoprim and then it works well together to enhance getting rid of the speck getting where the bacteria it’s a broad-spectrum antibiotic it works for a variety of things and it does suppress bacterial growth now this works by inhibiting tetrahydrofolate acid so it’s a derivative of folic acid or folate and what it this specific tetrahydrofolate acid
It suppresses bacterial growth by inhibiting that that’s part of the bacteria all right so it’s the first drug available for systemic treatment of bacterial infection so sepsis but now there’s more effective and less toxic drugs available so i’m talking about sepsis but it’s still used for other things and it hits a synthesis of folic acid which i had talked about
So mammalian cells do not manufacture their own folate not affected as bacteria are affected i don’t really know what that means which i’ll tell you the truth but i do know that bacteria has a derivative of folic acid and the way these drugs were put together is to inhibit that folic acid tetrahydrofolate acid in the bacteria and so that’ll suppress bacterial
Growth i hope that makes sense what these are permanent primarily used spirt now is utis it’s also used for myrrh so and put together with the trim the prime chlamydia it’s it can be used for although it’s not first-line for chlamydia can be used for chlamydia all sort of colitis it can be used for all right so some adverse effects with any sulfonamide there’s
Other sulfus out there such as hydrochlorothiazide for hypertension there is sulfasalazine which we’ve already talked about there is burn ointment that can be used for that and that’s a self a derivative you may see those use like in nursing homes or on burns but some adversity van johnson syndrome some hematologic effects connect terrorists which is with your
Eyes renal damage from crystals area so steven johnson syndrome i know i touched on that in class a little bit but it’s a really severe hypersensitivity reaction as causes basically you are breaking out in big blisters from the inside out it’s just burns this is awful drug interactions you can have some hypersensitivity to just other drugs so you just have to look
Up to make sure that they’re not interacting microbial resistance so there are some resistance especially among gan okok simonandjo cox i so don’t use it for meningitis streptococci shigella so you’re not going to use it if you have a shigella you see with diarrhea and streptococci which you could see with like strep pneumoniae and that kind of that bacteria it’s
Not gonna work for that all right all right so the silver sulfadiazine that is what i was talking about and matthan id which i’ve never used but i’ve used silver silvadene before and that’s another self so what that does is suppresses the bacterial colonization in patients with second and third degree burns again i don’t see the maffin i’d use it looks like it can
Cause some acidosis and it can be painful when applied so the silver silver silver’ dean a mentor silvadene ointment it’s usually pain free and it does get absorbed systemically this or anything on the skin can be absorbed systemically then we have the trimethoprim and this works again with the folic acid so when you have the both together the the sulfonamide and
The time method perrin tor methoprene it just is an additive effect so that we have bactrim so it’s back from double-strength it’s called and this is also can be used in utis which you’ll see ecoli protease klebsiella these are all bacteria that are in acute urinary tract infections again this can have some hematologic effects can cause some hyperkalemia and you
Can use this you should not use this in pregnancy and lactation but now we mix the two together is what you’re going to see you can you will see this definitely in your career and it’s called bactrim you’ll see it as to the trimethoprim safa method methos is all and tpms mz you may have already had this prescribed to you before and it’s used commonly for utis it’s
Actually one of the first line with makarov it is number one we can also do an alternative of the back drum otitis media bronchitis shigellosis because when it’s combined it can work for that pneumonia caused by pneumocystis pneumocystis pneumonia gi infections definitely there’s some adverse effects gi stuff so you have them take it with food all these antibiotics
You’re gonna have them take with food unless it says take on an empty stomach you take it with food remember the steven johnson syndrome watch you really don’t if they’re just taking a seven day course and if they’re healthy you don’t need to watch labs or high potassium but just know that it can cause hype ok hyperkalemia you can get a sulfur rash and that’s it on sofas
Transcribed from video
Sulfanomides By Dr. Jennie Peters
