We answer questions such as: What is sulfamethoxazole trimethoprim , What is sulfamethoxazole trimethoprim used for?, How to take trimethoprim sulfamethoxazole, When to take trimethoprim sulfamethoxazole, and we will also explain its mechanism of action, side effects, dosage (oral, intravenous), uses, contraindications, warnings, pregnancy and indications.
Hello welcome to my channel subscribe or like if you like today we are going to talk about the medicine sulfamethoxazole and trimethoprim we will explain its mechanism of action its side effects its dosage its uses its contra indications its warnings pregnancy and indications the brand names of sulfamethoxaz and trimethoprimar bactrim septra cotrim sulfatrim
Soul trim bactelin ectaprim ceptrin sulfurt trimexes all mechanism of action of sulfamethoxazole and trimethoprim sulfamethoxazole competitively inhibits the use of paraminobenzoic acid paba in the synthesis of dihydrofolate produced in the bacterial cell producing bacteriostasis trimethoprim reversibly inhibits bacterial dihydrofolate reductase dhfr an enzyme
Active in the metabolic pathway of folate which converts dihydrofolate into tetrahydrofolate depending on the conditions the effect could be bactericidal thus trimethoprim and sulfamethoxazole block two consecutive stages in the biosynthesis of purines and thus essential nucleic acids for many bacteria this action produces a marked enhancement of the in vitro
Activity between the two agents therapeutic indications of sulfamethoxazole and trimethoprim oral first choice in adults adolescents infants and children over six weeks for treatment and prevention of picarini pneumonia primary prophylaxis of toxoplasmosis nocardiosis meleoidosis second choice in acute otitis media acute exacerbations of chronic bronchitis in
Patients without risk factors acute uncomplicated infections of the urinary tract cystitis phylonephritis infectious diarrhea treatment of toxoplasmosis granuloma inguinally donovanosis brucellosis intravenous first choice in adults and children over two months for treatment of picarini pneumonia nocardiosis second choice for the treatment of toxoplasmosis
Listeriosis and infections with methicillin-resistant esorius mrsa strains such as osteomyelitis and septic arthritis or skin and soft tissue infections side effects and adverse reactions of sulfamethoxazole and trimethoprim candidiasis hyperkalemia headache nausea diarrhea skin rashes other adverse reactions identified after evaluation of pharmacovigilance
Data acute febrile neutrophilic dermatosis sweet syndrome pathology of sulfamethoxazole and trimethoprim sulfamethoxazole trimethoprim oral adults and children over 12 years old 800 and 160th of a milligram slash 12 hours infants and children under 12 years average dose 36 of a milligram kg slash day from 6 to 12 years 480th of a milligram slash 12 hours from 6
Months to five years 240ths of a milligram slash 12 hours from six weeks to five months 120ths of a milligram 12 hours after seven days of treatment re-evaluate intravenous perfusion after dilution adults and children over 12 years old mild moderate infection 800 and 160 of a milligram slash 12 hours severe thousand infection hundred three hundred twentieths of a
Milligram six to twelve hours children two months to twelve years medium dose sixteen slash three point two milligrams slash kg slash twelve hours from six to 12 years 480th of a milligram slash 12 hours from 6 months to 5 years 240th of a milligram slash 12 hours from two to five months 120 of a milligram 12 hours uncomplicated urinary infection and infectious
Diarrhea 800 and 160th of a milligram slash 12 hours in children 25 fifths of a milligram kg 12 hours 3 days pneumonia due to picarini treatment in adults and children 75 to 115 to 20 milligrams kg slash day in two or more divided doses two weeks prophylaxis adults eight hundred and one hundred sixtieths of a milligram slash day seven days or eight hundred and
One hundred sixtieths of a milligram or one six hundred 600 320 of a milligram slash day three times slash week in alternate days children from 6 to 12 years old 480ths of a milligram slash 12 hours seven days or three times slash week in alternate or consecutive days children 6 months to 5 years old 240ths of a milligram slash 12 hours 7 days or 3 times slash
Week in alternate or consecutive days children six weeks to five months 120 of a milligram slash 12 hours seven days or three times slash week in alternating or consecutive days maximum 1 600 320 of a milligram slash day toxoplasmosis primary prophylaxis adults and children over 12 years old 480th of a milligram slash day or 800 and 160th of a milligram three
Times slash week or eight hundred and one hundred sixtieths of a milligram slash day children seven hundred fifty one hundred fiftieths of a milligram slash m2 per day max 1600 320 of a milligram slash day treatment in adults no data in children 25 fifths of a milligram kg 12 hours six weeks granuloma inguinally donovanosis 800 and 160ths of a milligram slash
12 hours three weeks or until lesions disappear nocardiosis 50 75 tenths to 15 milligrams kg slash day in two or more divided doses three to six months in case of cns infection disseminated infection or existence of immunosuppression duration of treatment greater than one year brucellosis adults and children over eight years old eight hundred and one hundred
Sixtieths of a milligram slash twelve hours six weeks children under eight years old first choice treatment twenty-five fifths of a milligram kg 12 hours six weeks meleoidosis 40 eighths of a milligram kg 12 hours three to six months listeriosis adults 10 to 20 milligrams slash kg slash day in two to four doses two weeks in patients with bacteremia and two to
Four weeks in patients with cns in immunosuppressed patients three to six weeks in bacteremia and four to eight weeks in cns affectation children 50 60 10 to 12 milligrams kg slash day in four doses 14 to 21 days osteomyelitis and septic arthritis adults 3.4 to 4 milligrams slash kg slash dose slash 8 to 12 hours pure lynch cellulite adults 800 to 1600 and 160
To 320 milligrams slash 12 hours children 20 to 30 slash from four to six milligrams kg 12 hours skin and soft tissue infections adults 800 and 160 of a milligram slash 12 hours mode of administration of sulfamethoxazole and trimethoprim oral take with food or drink to minimize any possible gastrointestinal upset intravenous route perfusion should be 60 to 90
Minutes contra indications of sulfamethoxazole and trimethoprim history of hypersensitivity to any of the active ingredients or to sulfonamides premature infants and children six weeks old oral route or less than two months old intravenous route suspected or confirmed diagnosis of acute porphyria documented megaloblastic anemia due to folate deficiency severe
Renal failure severe liver failure also by oral route concomitant treatment with dopalite also by intravenous route pregnancy and lactation warnings and precautions with sulfamethoxazole and trimethoprim resistance of microorganisms involved in acute otitis media and acute exacerbation of chronic bronchitis s pneumoniae and uncomplicated urinary tract infection
E coli may vary from country to country the health professional should take into account local resistance data rare cases of death have occurred due to severe reactions including full moon and hepatic necrosis agranulocytosis aplastic anemia other blood discharges and respiratory system hypersensitivity do not administer to patients with severe hematological
Disorders except under close medical supervision severe skin reactions such as stephen johnson syndrome and toxic epidermal necrolysis have been reported monitor and stop treatment if they occur hypersensitivity reactions with eosinophilia and systemic symptoms dress may occur perform blood counts monthly especially in prolonged treatment elderly and folate deficit
Caution in renal insufficiency adjust passology liver parenchymal injury elderly g6 pdh deficiency risk of hemolysis phenylketonuria patients at risk of hyperkalemia and hypernatremia monitor na and k not recommended in treatment of pharyngitis due to beta hemolytic streptococcus group a s pyogenes maintain adequate diuresis risk of diarrhea and pseudomembranous
Colitis due to c difficile also an intravenous route caution in patients with severe allergies bronchial asthma or aids liver failure and sulfamethoxazole and trimethoprim contraindicated in severe liver failure caution in patients with liver parenchymal injury renal insufficiency and sulfamethoxazole and trimethoprim contraindicated in severe insufficiency
Interactions with sulfamethoxazole and trimethoprim contraindicated with daphaelitide risk of ventricular arrhythmias associated with prolongation of the qt interval including torsade the pwant risk of thrombocytopenia and hyponatremia with diuretics especially thiazide especially in the elderly risk of megaloblastic anemia with doses greater than 25 milligrams of
Pyromethamine monitoring with zidovidine lumibutine warfarin phenitoin oral antidiabetic sulfonylurea type increases effect of antidiabetics adjust dosage antivirals zedovidine zalcidibine lamivutine amantidine immunosuppressants tacrolimus oral anticoagulants warfarin antiarrhythmics procainamide digoxin anti-epileptic phenitoin antibiotics rifampicin dapzone
Methotrexate reversible impairment of renal function renal transplantation with cyclosporine competitive inhibition of active renal secretion with substances forming cations at physiological ph for example procainamide amantidine may increase both plasma concentrations increases plasma concentration of digoxin in the elderly caution with medicines that produce
Hyperkalemia ace inhibitors potassium amino benzoate local anesthetics ethanol foods rich in potassium potential risk of myelosuppression with methotrexate pyrimethamine methotrexate mercaptapurine azathioprine administer folate supplement inconcomitance with methotrexate or antiphyllate alters the metabolism of phenylalanine prolongation of the cutie interval
With anti-arrhythmics procainamide quinidine antipsychotics chloropromazine haloperidol antidepressants mipramine antifungals ketoconazole antibiotics erythromycin antihistamines terphenidine astemizol lab interferes in the determination of methotrexate with lkci dihydrofolate reductase of plasma creatinine with alkaline picrate reaction interferes in thyroid
Function tests pregnancy and sulfamethoxazole and trimethoprim trimethoprim and sulfamethoxazole cross the placenta and its safety in pregnant women has not been established trimethoprim is a folate antagonist and in animal studies both substances have produced fetal malformations case control studies have shown that there may be an association between exposure
To folate antagonists and birth defects in humans therefore cotrimoxazole should be avoided in pregnancy unless the potential benefit to the mother is greater than the potential risk to the fetus and a high-dose folate supplement up to four or five milligrams slash day may be considered if cotrimoxazole is used during pregnancy sulfamethoxazole competes with
Bilirubin for binding to plasma albumin when given to the mother before delivery there may be a risk of precipitating or exacerbating neonatal hyperbilirubinemia with a theoretically associated risk of kernicterus as significant plasma levels of the maternal drug persist in the newborn for several days this theoretical risk is particularly relevant in children
With an increased risk of hyperbilirubinemia such as premature babies or children with glucose 6-phosphate dehydrogenase deficiency socramoxazole administration should be avoided in late pregnancy breastfeeding and sulfamethoxazole and trimethoprim trimethoprim and sulfamethoxazole are excreted in breast milk when children have or are at particular risk of
Developing hyperbilirubinemia are premature or have glucose 6-phosphate dehydrogenase g6pd deficiency catrimoxazole should be avoided in nursing mothers effects on driving ability with sulfamethoxazole and trimethoprim the influence on the ability to drive and use machines is zero or negligible you
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Sulfamethoxazole trimethoprim used for?, Sulfamethoxazole Trimethoprim in ENGLISH By Medicines/Diseases
