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Where learning medical concepts is as easy as watching cartoons in this video, we will see benefits of sulfadoxine and pyrimethamine combination. this is our red blood cell and this is unwelcome malarial parasite growing in the cell. this is tetrahydrofolic acid required for various metabolic activity in the parasite. enzyme dihydropteroate synthase produces dihydrofolic
Acid using paba. then enzyme dihydrofolate reductase converts it into tetrahydrofolic acid. these steps are important for survival of malarial parasites. now, let’s give only pyrimethamine to this patient and see what happens. however, some of them start producing mutated dihydrofolate reductase. so, such parasites can keep producing tetrahydrofolic acid with help of these
New enzymes and grow even in presence of pyrimethamine. this resistance to pyrimethamine is a big problem, if pyrimethamine is given alone. now, let’s give sulfadoxine along with pyrimethamine. sulfadoxine is a sulfonamide and it inhibits dihydropteroate synthase. and pyrimethamine as we have already seen inhibits dihydrofolate reductase. which provides more complete
Inhibition of synthesis of tetrahydrofolic acid. if parasite develop resistance to one drug the other drug handles the situation. for example, let’s say here also parasite produces mutated dihydrofolate reductase but now, we also have sulfadoxine which is still working and preventing the synthesis of tetrahydrofolic acid. similarly, if it develops mutated dihydropteroate
Synthesis rendering sulfadoxine ineffective, pyrimethamine still works. that parasite will come of its mutation in both the enzymes together. so, resistance is much less of a problem, when both the drugs are given together. final answer is sulfadoxine + pyrimethamine = increased anti-malarial effect if you found this video helpful, please share it with your friends too.
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Transcribed from video
Sulfadoxine pyrimethamine Combination for Malaria By Nonstop Neuron
