(golden staph, oro staphira)
Staphylococcus aureus staphylococcus aureus a facultative aerobic gram-positive cockle round-shaped bacterium one micrometer in diameter it is non-motile and does not form spores they form clumps it is a commensal of the human microbiota but can also become an opportunistic pathogen for common causes of skin infections eg abscesses respiratory infections eg
Sinusitis food poisoning locations upper respiratory tract skin nostrils lower reproductive tract of women causes it is also acquired in hospital injury surgery use of intravascular devices eg catheters hemodialysis machines injected drugs symptoms pimples impetigo boils cellulitis folliculitis carbuncles scalded skin syndrome abscesses complications pneumonia
Meningitis osteomyelitis septic arthritis endocarditis life-threatening inflammation of the endocardium inner lining of hearts chambers and valves toxic shock syndrome bacteremia sepsis diagnosis physical exam for skin lesions eg abscesses furinkles cellulitis tissue sample nasal secretions for clumping factor coagulase hemolysins and thermostable deoxyribonuclease
Echocardiogram ultrasound examination of the heart staphylococcal virulence factors to promote infections toxins hemolysin leukotoxin exfoliative toxin enterotoxin toxic shock syndrome toxin 1 tsst minus 1 damage biological membranes leading to cell death hemolysins poor forming toxins the pore allows the transport of small molecules such as k plus and ca2 plus
Ions leading to necrotic death of the target cell enzymes coagulase hyaluronidase deoxyribonuclease lipase staphylokinase beta-lactamase for drug resistance degrade host molecules or interfere with signaling cascades and metabolic pathways in the host thermostable deoxyribonuclease breaks down the dna protecting itself from neutrophil extracellular trap mediated
Killing surface proteins bind and inactivate antibodies promote colonization clumping factor a clfa a cell wall anchored protein that facilitates the colonization and promotes bacterial adhesion to the fibrinogen blood plasma protein catalase converts hydrogen peroxide h2o2 to water h2o and oxygen o2 coagulase facilitates the conversion of fibrinogen to fibrin
To cause clots not all the strains are positive treatment antibiotics penicillinase resistant beta-lactams second-generation penicillins for infections acquired outside hospitals resistant to beta-lactamase bacterial enzyme dash vancomycin for hospital-acquired infection often caused by antibiotic-resistant strains dash trimethoprim sulfamethoxazole clindamycin
Minocycline linezolid or doxacycline against methicillin resistant s aureus mrsa and antibiotic resistant strain wound drainage making in incision into the sore to drain the built-up fluid in case of skin infection device removal removal of the device or prosthetic that may involve the infection you
Transcribed from video
Staphylococcus aureus By Air to air
