We’ve talked aloud about agents that typically kind of focus in more of the upper respiratory tract now we’re going to go down a little bit lower and start talking about the bronchi and canna the lower respiratory tract so our first class of medications we’re gonna talk about is our short-acting beta-2 agonists these typically are referred by to pay or by patients
As your reliever or sometimes rescue medications according to the national formulary of india you’re so beautiful inhaler is one of the products that is a short-acting beta agonist that is available when we look at the different products that are available more available worldwide other beta agonists that are beta-2 agonists that we see is albuterol which comes in
Multiple types of branded products as well as leave albuterol now if you look at the this particular type of medicine you what you’re going to notice if you remember um back if you remember back to some of your biochemistry organic chemistry days okay this is just actually the active isomer of the racemic mixture of albuterol okay now is there any difference between
The albuterol and the leave albuterol manufacturers of the leave albuterol would say that this formulation tends to have a little bit less side-effect profile however in clinical practice we don’t see that primarily as much if they’re using these products just as on an as-needed basis where there is a little more efficacy to show to support the leave albuterol use
Potentially maybe in more of that emergency or acute care setting where it’s being administered by a health professional so how does short-acting beta-2 nests work so short-acting beta-2 are able to affect the lungs by attaching to and relaxing the smooth muscle that wrap around the bronchi and they improve asthma control so they attach and then they help to relax
Those muscles typical onset of short-acting is less than 10 minutes and typical duration is going to be about four hours depending on how the patient metabolizes the medicine the most clinically significant side effects associated with short-acting beta-2 agonists or sometimes people will refer to them as sabhas is skeletal muscle tremor and tachycardia so these
Are great medications to have for patients who have respiratory diseases such as asthma or copd and particularly in our asthma patients they should always have a short-acting beta agonist available in case they get into trouble with an acute exacerbation of their asthma however we do not want them to be over utilizing these products because what can happen is you
Can see a down regulation of that beta receptor in the lungs and then this medication when they really need it will not be as effective and so increase use of greater than one canister per month is an indicator of a patient’s over reliance on the short acting medication and may increase the risk for life-threatening exacerbations and this primarily is associated with asthma
Transcribed from video
Short Acting Beta 2 Agonist By TeachGlobal
