Hi i’m going to talk about serious asthma even with buta sodium plus formoterol versus the dessaline alone but ground search mean about the safety of our in long-acting to agony’s to inhale a group article for the treatment of asthma in a post-marketing safely study managed by the food drunk and food and drug administration we value eight whether the elysium offer
Material to blue saline maintains therapies increased the rest of the see us augment relate event in fashion with us we now see a video let’s discuss asthma asthma leads to increased airway reactivity bronchoconstriction obstruction and in severe cases respiratory failure it primarily affects the small airways normal small airways are composed of a smooth muscle
Cell ring mucosa and mucous which is produced by cells in the mucosa acute asthma is due to exposure to an environmental trigger something like dust animal dander pollen smoke even exercise or respiratory infection there are two immune response pathways that contribute to asthma symptoms the first response is rapid and is due to mast cells that are found in the mucosa
Mast cells have ige molecules on the surface when these bind an antigen like part of an allergen the granules in the mast so release histamine and pro-inflammatory substances there is also a second delayed immune response helper t-cells also bind the allergen and release pro-inflammatory cytokines that stimulate b-cells to release more ige and recruit both neutrophils
And eosinophils to the mucosa as these cells arrive the mucosa becomes inflamed and further enlarged which causes both increased airway reactivity and worsened obstruction this second immune response peaks 4 to 12 hours after allergen exposure both the immediate mast cell response and the delayed immune response caused small airway changes the smooth muscle layer
Becomes thickened and contracted due to bronchospasm and the small airways smooth muscle contraction is induced by histamine and leukotrienes binding to specific receptors on the cell membrane when prevents acetylcholine from binding impairing smooth muscle contraction the peak effect is within fifteen to thirty minutes steroids are also routinely given steroids
Impair the helper t-cell pathway with various anti-inflammatory effects it should be given early to miss like albuterol it impairs acetylcholine release and it decreases histamine release finally we have terbutaline terbutaline like albuterol is a selective beta-2 agonist so it works on the same receptor it has a worst side effect profile than albuterol but can be
A benefit because it is given iv making it easier to achieve a therapeutic effect in the small airways untreated severe asthma leads to respiratory failure and respiratory support should always be paired with medications first-line is oxygen if patients are still in distress despite oxygen and medications consider positive pressure ventilation or even intubation
Now continuing with position we have metals the primary endpoint was the first series as milady vein in a composite of a duty death intubation in the translation as i said in time to be vein another analyzes then known impurity of buddha saline for material to be loosening was defining us an upper limit of the 95% confidence interval for the width of the primary
Safety endpoint of less than two points point zero the primary efficacy endpoint was the first as much as a ratio as i said in a time to even analyze and let’s go to see another video most people don’t know actually 25% of the er visits are related to a spa 30 cm thought a given day 36,000 people miss work do the asthma 27,000 kids miss school do the asthma is in
Fact it’s the number one chronic disease amongst children so it has a major impact 18 billion dollars to cost to insurance companies individuals waspers productivity times personal time etc so it has actually a huge impact up to half a half a million hospitalizations a year so it is a very big deal at dell his position to treat the prediction of a critical asthma
Event in ways that nobody else can so with that what we can do is we can hook in to those traditional medical sources with bhumi through our agent as well as all the different api’s it’s known that obviously air quality has an effect on asthma so noaa the national oceanic atmospheric agency they have dated by zip code they want to make sure that they’re on their
Nebulizer inhaler whatever medications they’re on and then lastly we are helping the eevee staff so we’re pushing out not only a patient list to the emergency rooms were also pretty elevated forecasts of results a total of eleven thousand six hundred ninety three fashion underway in run randomization of who 500 5846 worth a singing to receive buddhist a name for
Madonna a five thousand eight hundred forty-seven to receive with the swing a serious asthma relate event occurred in 43 passion who where were saving buddha saline for material and in forty passion whoever save him felicity another result but the name promoter was show to be known further to buddha sitting alone there were two husband relayed that both in the
Buddha sodium formoterol growth one of this passion had undergone an asthma related intubation the rest of enhancements reservation was sixteen point five five percent lowered with buddha salim formoterol talked with buddha saline and we have another video dr. bobby zarin here the medical news minute listen growing up can be tough for some kids even worse is if
You happen to be saddled with a chronic illness like asthma a recent study published in annals of allergy asthma and immunology looked at the potential relationship between adverse childhood events such as experience domestic violence drug abuse a fairly death or parental separation and developing asthma the research team led by dr. robyn wing found that children
That had experienced one adverse childhood event a 28 percent increased risk of developing asthma the study was not a cause-and-effect study but an observational study but even so there’s an important take-home message keep not only your child’s physical environment free of factors that can increase the risk of developing asthma like cigarette smoke and air
Pollutants but also be sure their mental and psychological environment is healthy pollution among the dosing and adult with predominantly the motor right to serve as much treatment with bersonin for motor what is resilient with a lower risk of asthma exacerbation than put the city in similar rates of serious asthma related events here we have the last video this
Animation will show what happens in the lungs during an asthma attack at how a reliever inhaler works to treat it wheezing your chest may feel tight and you may be breathless the muscles in the walls of the airways tighten at the inner surface swells causing the airways to narrow an asthma attack can be triggered by exercise or an allergy for example both of which
Can irritate the airways when the airways narrow it’s harder to breathe reliever inhalers are used to widen the airways so you can breathe more easily if you have an asthma attack the inhaler contains a gas which propels the medicine into the airways so that the muscle walls relax and the airways open up when the airways widen it’s easier to breathe this is the
End of the animation click on the animation screen to watch it again and watch the video this animation will show what happened
Transcribed from video
Serious Asthma Events with Budesonide plus Formoterol vs. Budesonide Alone By Carlos Vicente Vélez Cojitambo
