🩹 Dermatology Course:
Welcome back in this video we’ll talk about the anti-diabetic drugs glp1 analogs and ddp4 inhibitors glp-1 analogs are the drugs ending of the sufflex tide and ddp4 inhibitors are the one ending with the sufflex gliptin they’re both used to treat type 2 diabetes where insulin resistance is very high glp-1 is actually a natural substance that is released after the
Ingestion of carbs glp1 basically prepares the body for the surge of sugar so when the food is inside the stomach and before it exits the stomach into the intestine glp1 rises sharply which results in insulin release and decreased glucagon release it also decreases gastric emptying and increases satiety to buy itself some time for its action to take course so
We came up with a molecule the glp-1 analogues that closely resemble this drug and it can work exactly the same way once we inject glp1 analogs into the body even if the stomach is empty it will result in increased insulin release and decreased glucagon release this drug was very expensive when it came out so there was a pharmacological race and another company
Came up with a new class called ddp4 inhibitors they found out that the normal glp1 is broken down by an enzyme called ddp4 and if we can inhibit this enzyme we will increase the concentration of glp1 and so the class ddp4 inhibitors was born they’ve reached the exact same effects with a different mechanism of action invertibly by decreasing the breaking down
Of glp1 they increase its concentration and its effect later on the companies manufacturing glp1 did some extensive research trying to prove that their drug is better and it came out that glp1 is actually cardioprotective which is not the case for gdp4 inhibitors and this is a common part for questions there are only two anti-diabetic medications that are
Cardioprotective glp1 analogues like exenatide and sodium glucose co-transporter inhibitors like canagliflozin these are the only anti-diabetic medications with desired effects on the heart side effects wise glp1 are known to cause pancreatitis rarely and ddp4 inhibitors are known to cause nasopharyngitis and utis and here’s a small quiz for you so which of
The following anti-diabetic drugs has negative effects on the heart and here is the answer alright guys that’s all i have hopefully this helps and thank you so much for watching
Transcribed from video
Saxagliptin, Exenatide, and Sitagliptin – GLP1 Analogs and DPP4 Inhibitors By USMLE pass
