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You so i’m going to explain to you about the discovery of some food on mars right so moving on so how’s our timon was divided in 1913 the common pigments of asthma was injected ethane ethene and ab you liza a philippine f in a field caused volcko dilatation but he also cost cardiovascular side effect so is needed in 1940 i saw very many were synthesized
And also finally we placed their feet of lead for asthma treatments cause spock one correlations also taking please hartley and the effect was shocked i can’t cost a smart f in 90/60 nice an increase in asthma death in britain coincident with the increase in sale of a supinated inhaler do it that time i’ll supply amazing inhale was certain hydroxyl based on
These residents a new de was needed so david and his team there were many kinds of analog of i so feminine but the ended up must have done at the effect and relatively stable for order and intership to this kind of test shows that the reason beta agonists analog there was active in both cold muscle but do not affect the heart so during his time they reject
Optic there is a new beta receptor at banco muscle that do not affect the heart after series of tests and experiments a new platform that is subbu tommo in 1969 subatomic inhaler was launched in the market by fallon and and good as a highly successful asthma drop an altitude a sub bootable was still on the market so as ethylene and poppy bactine as you can
See we phone before as multi-well stopping affinity moving to ice apparently moving to subdue demo but doing this time that is vitally sector is still not fully understand so how actually support on or was it assist a dvd is non select if we can stimulate both alpha and beta is at f2 is a non-selective receptor for isis ideally is also enough selective we can
Stimulate beta but both beta 1 and beta 2 orbits agata more because at the medic beta 2 so it’s the only doctor is lactic for asthma demon but a statement during that time is not based on the receptor instead based on the function that they are looking for for example a little ding has one correlation this is what they want but it has cardio vascular side
Effect so they will be moved the fashion ago that causes cardiovascular effect and produce another of our annealing days i so paganella – i saw baggalini have both code validation that is what they want but it also has a little bit cardiovascular side effect so that we remove the fashion a group that cause cardiovascular effect what is a new analog that is
Sub you tomorrow so sammi tommo has vocalization and last longer there and in any other clock sagamore lasts about 4 hours this kind of block development actually do not based on the receptor but based on the fashion of the block before them in this part i’m going to explain about the mechanism of passion of subbu tomorrow as we all know subbu timon is one of
The victor to agonist which is a good wrong correlated use in the treatment of asthmatic disease but the question is how is the support amount going to work first of all after the administration of subbu tomorrow it will travel to the lung and bind to the beta 2 receptor this beta 2 receptor is actually coupled with g-protein by binding some bottom wall to the
Receptor it will activate the alpha subunit by changing the ddp with gtp so this alpha subunit is now free to activate the enzyme idly cyclist this enzyme is important when it involved in the signaling cascade so analysts cyclists will change the atp into cyclic aap this cyclic concentration of cyclic alp is very important in the physiological changes of the
Death it will in activates the myosin light-chain kinase and also decrease in the intracellular calcium ion this both factors – enlighten kinase and also the concentration of the intracellular calcium ion is very important in the smooth muscle constriction so here by inhibiting these two factors it will result in the smooth muscle relaxation hence we can treat
The asthma tips in terms let’s see how modification of chemical structure can overcome the issue of signal to selectivity okay first of all we have adrenaline so adrenaline is used at first two three asthmatic attacks in emergency situation but are generally able to bind to any regular at unity receptor so it make us to unwanted cardiovascular side-effects
So to have a truck more selectivity to a cemetery sector so we add we have iso paneling but the problem if iso paneling is that international selectivity to the different subtype of the character and it still cost unwanted cardiovascular side effects so the rhesus just come up with little drop which is i saw a terrine so i saw a terrine is proven to be better
To selective so notice the difference between the three drugs over here so the progression from the non-selective to be that selective is due to the addition of aalto substitute here so because of this action of auto substitute my second allele is small selective to its military scepter okay between isaac renewing and i saw battery the difference that cause i
Saw it early to be more because relative as this alkyl substitute here so because of this the presence of this of the substitute a making our model active to its bitter to receptor the last time we had successfully overcome the issue of beta 2 receptors activity but now there’s another issue which is i saw a terrine is metabolized by catechol ohmic contacts
Erase off in short zero empty so in order to overcome this issue we change the hydroxy in ethylene group over here so when we change the functional group it is proven that this the cod molecule is not metabolized by c or empty so this molecule is now known as how to come up when the patient inhales about them.all ten to twenty percent of health about allah
Will reach tula and perform in action while in ninety eighty to ninety percent of support among through the smell of down gastrointestinal tract and in absorption from the jit will pass through the first plastic right in deliver now portable is readily applauded property id the inactivation of the optimal by deliver the best create enduring as unchanged truck
And also its conjugate majority of the in health of ottoman robust lifted from the body within 72 hours so moving on to the issues of salbutamol as a drug of choice offer to asthma attack so first let’s watch a video made by our good friend so take it away so moving back to me i will presently the second issue which is the ultimate forms of salbutamol
Every terminal contains both r and s anything will form but is the cash and the other bottom one is safe and has more affinity towards the target receptor and s are become worse are commonly associated me touch is the effect and has lower affinity so it is not people so in response to this a new drug by the name of level patrol was develop it contains only they
Are an intermediate form of subatomic making it safer and more so more efficient compared to subject among the problem with this is that level boot are all isn’t really cheap so not a lot of people can use it and so this inhibits it was its widespread use throughout the world now now this question which one is actually better now when we consider the economic
Effect of course our become a little bit better because not only does it deliver a suspect properly it’s also cheaper but you know those who are more you know more economically stable my consider level boudreaux because it is much safer and more effective than some butum all know certain asthmatic patients are given long-acting beta agonist but here’s the thing
Why why isn’t long-acting beta agonist considered enough to counteract the q as well it does i mean each time we have a few asthma theater so i could just administer a long-acting beta agonists now one thing that i found about long-acting beta agonist is that it is not effective against acute asthma theaters now this could be for a number of reasons it could
Be because of the absorption profile or etc as a trap but but nonetheless it’s not effective against a cosmetics but not only that i mean you might be thinking well see we could just increase the dose but then long-acting beta agonist is proven to be unsafe because the fda have found it may worsen asthmatic symptoms known as exacerbation also when we consider
The convenience for the patients and for the health provider we can see the estimate on a metallicity smash that day because for labor for long-acting beta agonist it requires heavy consideration from the patient side as well as strict control by the health provider so when when we consider this practice we we might say that you know short-acting betta ignace
Is much more better in terms of efficiency safety and also convenience in in terms of conquering the cube as matilda’s so that’s all for me thank you so that’s all representation from earth i hope you enjoyed the video i am kumar from good 12 and we would like to say
Transcribed from video
"Salbutamol is the drug of choice for acute asthmatic attack" By Rx15 Kulliyyah of Pharmacy
