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Hello everyone what’s up this is uh here from zmetz and today let’s discuss celbutamole that is also known as albertorole and this drug is going to act on the respiratory system means on the lungs or the bronchioles so it is highly selective beta-2 agonist okay means it is totally going to act on beta2 receptor that is present in the lungs that is present on the
Bronchioles or the bronchi and it’s not going to act on other beta 1 beta 3 receptors this drug is going to act on beta 1 and beta 3 in only one case when there is overdose of this agonist so selectivity can be enhanced if we introduce the drug through inhalation because we will we will prevent the drug from going into the blood circulation and everybody knows
That when drug goes into the blood circulation then drug has to rotate throughout the body and can produce side effects so next we have our macrodynamics means the mode of action obviously i have told you that it will act on the beta2 receptor and it will cause the spasm to go away and will cause the relaxation of the bronchioles known as the bronchodilation next
We have the therapeutic uses of this drug now if someone is having asthma attack then he or she can use this drug means during emergency condition you can go for the albuterol or cell butamol but if you’re expecting uh lifetime prevention from asthma then you are wrong you can’t use the drug before asthma attack okay if you are suffering from asthma attack then
You can go for the alberto or cell cell butamol so no prophylactic use side effects profile is a bit lengthy but it doesn’t mean that it’s going to happen to everyone it will happen to those individuals who are taking high doses of albuterol or cell butamol muscle tremors palpitation these two are the beta 1 and beta 3 effects restlessness it’s and nervousness
These are the two actions on the brain or the central nervous system then throat irritation obviously when you are going to inhale something it will go into and it will pass through your throat and when it will pass through your throat so it means there will be irritation on the throat and cough may be introduced then ankle edema this is also uh a peripheral
Effect due to the rare non selectivity of this agonist then hypokalemia as well now for macro kinetics most of the time cell butter mole and albeit our albuterol are taken with pressurized meter dough metered those inhalers and why it is known as metered dose one puff is equal to specific amount of drug to be introduced in our body in our lungs in our respiratory
System so that’s why it is known as pressurized metered dose inhalers and it enhances the selectivity towards the beta receptors now the onset of action means action starts within two minutes so that’s why it is good to be used in the emergency conditions duration of action is two to four minutes but its duration can be increased if we take the drug orally but
When we take the drug orally selectivity will be compromised and obviously onset of action will also be compromised and will delay the onset of action so if we take a cell butamol or albeotrol orally then it’s going to give 50 concentration of the actual amount of the drug while in case of inhalation there will be no wastage of the drug and whole of the drug
Will go in our lungs will go and bind to the beta2 receptors so in case of oral cell butamole there is more duration of action that is four to six hours but i will not prefer it so that was all about cell butamole or albiotrol and we and you can take cell biodemon in the form of salvo it’s also found in the combination with inhaled corticosteroids such as a
Fluticasone buddhisonite and we may discuss these things in the later on videos and also if you want to know about uh um about these drugs in here corticosteroids are other short acting are long-acting beta-2 adrenergic agonists then i will give the links of those videos in the description box below so you have to follow those links until next time it’s hip tire from zmez signing out
Transcribed from video
Salbutamol/Albuterol – Therapeutics uses, Mode of Action, Pharmacokinetics, Side effects By ZeD MEDS
