****Gs does not lead to the production of ATP it only stimulates the conversion of ATP to cAMP
Okay so i’m just gonna do direct sympathomimetic pathway of all of the beta activators they work in different places but we’re going to just do you know do all of them because they’re all the same kind of like idea pathway okay so we have beta 1 we have beta 2 we have beta 3 ok and it activates a receptor wherever it’s acting that’s going to activate the g s s
For stimulation because g s is going to eventually result in the production of atp how does it do this it acts on a dental ill cyclase which is a converter enzyme because it ends in with a pace so it takes atp and it converts it to cyclic a and p cyclic am p is going to activate a kinase but do you know what which kinase is going to activate protein kinase which
One hey because we’re talking about atp so that corresponds to that and it’s adenylyl cyclase for that reason because this is adenosine triphosphate ok so the protein a kinase has two actions ok it’s going to act on the myosin light-chain kinase now this is a kinase itself what our kinase is good at they’re good at phosphating phosphatidyl so the protein kinase
Is going to fought it’s gonna phosphatidyl iesson light-chain kinase deactivating it so i’d really like to make this you know inhibition and this is going to be activating this is just not neat enough for my ocd so i’m gonna have to erase it excuse me well i do that okay so we have myosin here great so protein kinase a will also stimulate kind of the release of
Calcium in its location increase in the sodium concentrations there and in the heart this has the effect of increasing contractility so that has a i know tropic effect as well as a heart rate i’m just gonna put hr i hope you don’t mind you will need to know that acronym there so abbreviation so so that’s going to be great but why are we doing this well if your
Patient has asthma why would you use this for a beta 2 that’s that okay so let’s say that you’re using albuterol i’m going to use it over here though sorry it’s tough to switch over to it so albuterol albuterol is is a sabra or lama it’s a sabah so it’s a short-acting beta-2 agonist so short-acting beta-2 agonist so which of these is acting on detecting on beta 2
So beta 2 acts in the bronchi and what it actually does which i’ve just learned is it fosse’s a what does it do okay so yeah so that’s what we’re talking about here okay so the myosin light-chain kinase so what this winds up doing is it used to phosphatase the mice and the myosin involved in the action of mice and cross bridging and the activation of the muscles
There in the smooth and smooth muscle in the bronchi for a constriction but because that doesn’t happen what you get is relaxation relaxation of the bronchi so that’s great because your patient has you know this is probably administered through some kind of puffer and your patient has asthma so they’re trying to open up that large airway or the bronchi so the
Beauty of this is it’s going to relax these we have muscles in the bronchi the problem with it and i’m just going to put this stupid thing is you have beta one activation as well so that’s also going to increase your heart rate so you got to be a little bit worried about that because on occasion that’s not ideal and then there is of course some adderall and that
Is is that a sabra lava of course it’s a lava because we already talked about osama and that acts in the bronchi as well but it has better specificity and does not have this bated one activation which will increase your heart rate i hope that’s a reasonable explanation of a saba and a lava pathway and i’m gonna make this sawn off here just a little bit of urination
It has nothing to do with what we’re talking about you know what you know what micah do urination today we’re gonna do some air because our airways are opened okay cool see ya
Transcribed from video
SABA and LABA drug pathway tutorial By Axxx Kxxx
