This week we will continue with the second part of the synthesis of phenytoin where we are going to oxidize the benzoin to benzoyl compound benzene can be oxidized to benzoyl compound using different ways in our experiment cobbold oxidation using kubrick ion as the catalyst transfer oxidant will be used in a doubled oxidation the overall oxidation proceeds in two
Distinct stages as you can see the capric acetate is used in catalytic amount and this continuously reoxidized from the reduced copper estate by ammonium nitrate which is a present an excess amount and is reduced to ammonium nitrite which decompose in the reaction mixture into nitrogen and water actually these kubrick salts are mild oxidizing agents that do not
Attack the tone product which is the benzoyl compound in the absence of capric the ammonium nitrate will not oxidize the benzoin or benzyl at a significant rate now this is the last benzoin product now we wait 1.75 grams from it weight point a two grams of ammonium nitrate now in a round bottom flask add the 1.75 grams of benzene now add 5 ml of a glacial acetic
Acid the point eight ground of pulverized ammonium nitrate and finally one ml of kubrick acetate solution and after 1/2 an hour and reflux condenser cool your solution to affect your 60 degrees in a pika now more than an l of cold water your mixture understanding it put it in ice baths in order to start crystallization for 10 minutes after cooling for around 10
Minutes we will start suction filtration to collect the product which is the pantheon use the simple check what an anything finally your project is ready
Transcribed from video
Phenytoin Synthesis step 2: oxidation of benzoin to benzil By Isra Tayseer
