Discuss about and here maybe clicks these are the drugs that are useful in the infection caused by anaerobic rota java especially entamoeba histolytica because other crossover are related with non-pathogen this is most important package mechanism in the proto java and these are can you know this ducts they act unless this anaerobic produce over okay then coming to
Classification of antiemetic drugs we can spray this and mmm just mail into this for me besides under malawi besides okay in the tea swami besides we have two categories one is that lots of attacks both on either side of the next site interesting everybody asses another one is then that attacks only on x i it has no olivia says okay you come into the ducts which
Access both both inter 7 and x tiger several of you assets we are mainly together groups of x 1 is nitrogen and other ones are christ’s throny asteroids in itil merger we have metal we have met tourism tourism sick netizen on it is own saturn is own interests we have products emitting and denied the minimal okay i mean to that recipe jacksonian extra interstate
Only we have some only we have wonder that is chiropody and the coming to the blocks the taxon even lobby male sex only basis amigo sex we have mainly three closer drugs one is inhibits emits how much is a tie jackson penalized and then one maurice antibiotics come in two types we have that up tonight for a bit they have denied today and it is awesome i do okay in
Eight ataxic penalize we have one the single that in idaho in a doctor then coming to an antibiotics we have mainly to go doctor seconds and caramelizing okay then come people in this darkness lift exit mainly focus on materialism because this drug is very often used nowadays right that’s the reason might be how we are discussing this in this lecture and this very
Pond cousin per hour your sections also so let’s start practice cutting here and this metal it is not it’s the prototype of okay it is a prototype of naturalism and it acts i just made me another with protozoa and another big bacteria and also micro arrow arrow flick organism spoken come into spectrum and roger that – which attacks are icomos personalized giardia
Lamblia and interviews melodica okay mr. writer then coming to bacteria and i switched attacks will mainly close today’s basis bacteria its use a bacterium peptostreptococcus number back there and h pylori it also acts on it that means list medicines talking less but it says we said when you’re on break and it also has stepped up okay and emily and ooby step like
Okay and alcinous spirochetes an arsonist correct then we know to mention of accent mechanism of action this literalism it acts a special agonist selective language i’m gonna be cutting some as it is presume or bacteria first in the mechanism arts acts in the mechanism of action it starts with a dictation of the drug into the organism okay first attack will diffuse
Into the organism here it is protozoa are back again okay diffuses into the bacteria in the bacteria this night will do this nitro group of metals are will be reduced to nitro editor this nitro radical is highly reactive this reaction is done by some reductions which are there in the protozoa okay let us see the energy generating system in the bacteria anaerobic
Bacteria are crossover ok energy generating system see in the in the bacteria approach over there is a pathway cut pf war ends in pathway in jail partly this is this expanded furnace pyruvate pyruvate ferredoxin oxido reductase enzyme pathway they written right here pyruvate the rhodopsin oxido reductase oxido reductase pathway in the pathway in the bucket but
What happens is in this pocket there is generates enough electrons there is production of lacrosse these electrons are taken up an asset to accepted by some electron acceptors from some electron acceptors in the bacteria we accept this electrons okay this is not healthy not not that i can see protégés again other metal is and what it does is metronidazole this
Metal result will compete with these the connectors will compete with these electron acceptors thereby preventing the production of energy in the protozoa thereby preventing the product energy generation are disturbing the energy generation system in the protozoa preventing and disturbing them energy generation process in the prefer this is a mechanism in factions
Okay but the reason why we met original is in active against arabic agencies in the arabic organisms in the aerobic organisms the very first step detection of nitro group to nitro radical this option okay this step will not happen in the aerobic organisms hence it is not operable in the arabic organism and moreover the oxygen which is there in the arabic quran
Some will also compete for the electrons okay then that means yet with three others there is increasing competition for l cross site you know but there is simply no competition for ryokan the action of metals will come down right so the reason why it does not act as aerobic organisms is one is the very first rip nitro group is not getting reduced to nitro radical
And another thing is that there is oxygen grants company for the electron hey this is the this the reason why it does not answer is there a mechanism suppose you come into resistance how this protozoa dangerous arabic carnism they become respect to these american one is a very so stable the very first step the efficiency of very first step will will come down the
Very first step that is this nitro group will be reducible nitrogen this step will be other and this capacity will come down and otherwise this pathway because you’ll also come down p p of are in the module also comes out these are the component mechanisms by which the protozoa are another will occur resistance against madrid result okay these are addressed less
Than coming to pharmacokinetics they’re coming to pharmacokinetics of metal itself in the form context it is orally well observe a no she’s completely of those through our rule okay corrado it’s almost completely absorbed it has got i worry about the exhibition good ball arrival about dismissing this metal attack it gives it there occurs throughout the calculation
They have to concentration emulation in the saliva csf but in our situations and even seminar okay there up the concentration of drug will accumulate in well see yourself saliva vaginal secretion and even semen okay in the metabolism matter body so he takes place in liver in the liver metabolism will take place mostly by oxidation karana is in conjugation okay
An acceleration will takes place the renal system protein and a half life is almost eight hours okay this is a form of kinetics then we move to adverse
Transcribed from video
Pharmacology of ameobocides (metronidazole) By S.L.V lectures
