#FixedDoseCombination #salmeterol #fluticasone
Can fix those combinations let us look at salman trawl salmet tirol actually sand material and flute ecozone okay so basically do you think through the rational drug combination first of all what is salma tear on salma tirol is actually a beta-2 agonist receptor alguna so it can be an adreno cheap drug right so it is a adrenergic receptor agonist so it is
A long-acting adrenergic receptor agonist what is beta to do meeta to will dilate the bronchus right so you remember here beta 2 though in here it is inhibitory but it will do bronchodilation right so basically you are giving here salmeterol with fluticasone now fluticasone is what it is a steroid correct so basically a salma troll is a long-acting beta to
Adrenergic agonist which dilates the bronchioles smooth muscles fluticasone is a steroid right preserved glucocorticoid it is it’s also a long-acting inhaled blue aquatic the glucocorticoid which decreases airway inflammation and reduces bronchial hyper responsiveness so basically it reduces the inflammation it reduces the hyper responsiveness so it is it’s it
Is a basically it is a steroid and now you have to tell whether these two can be given together so do you think this fixed dose combination is rational or not it turns out this is a rational fixed dose combination right now it is used in the management and prophylaxis of chronic severe asthma and copd so it for astra they can give this okay so inhalation it is
So what exactly happens is when you give salmet role to fluticasone adequately so what happens they control adequately control the chronic severe asthma so addition of salmeterol to fluticasone adequately controls chronic severe asthma okay it reduces the dose requirement it reduces the dose requirement and it also reduces the adverse effects seen with higher
Doses of glucocorticoids so as the dose of the corticoids come down so you will need less and hence they’ll be less side effects okay prolonged use of beta-2 agonist and down regulates the beta 2 receptors okay so basically prolonged use of beta 2 awareness is not very advisable they are safe so if you are giving salmet on long term what will happen the beta 2
Ago nests the receptors they get down regulated okay so the beta 2 receptors get down regulated in prolonged use and it is spread this this can be prevented by glucocorticoids this combination is rational so let’s make it green guys this combination is rational it is correct you can combine it okay salmet iran plus fluticasone
Transcribed from video
Pharmacology 998 c Fixed Dose Combination Practical Salmeterol Fluticasone Rationale Adrenergic By MBBS VPASS
