Part a
Hello people in this video let us look at left flow no might correct lefleux no might so leflonomide is a anti-rheumatoid drug correct we have already seen what rheumatoid arthritis is we have seen the classification of anti-rheumatoid drugs in that in the disease modifying anti-rheumatoid drugs under that non-biological agents and under that immunosuppressants are
They immunomodulated it’s an immunomodulator it’s an immune modulator it is not a immune suppressant it’s an immune modulator we have this uh sulphur salizine and then chloroquine and this leflonomide okay so what exactly about leflou nomide we should know this lepton lomide so what you have seen so far anti-rheumatoid drug so disease modifying anti-rheumatoid
Drug it is non biological agent it is a immunomodulator so what it does is it is used to treat rheumatoid arthritis correct that much you have understood right it is used to treat rheumatoid arthritis which is autoimmune disease correct so it is an immunomodulator this one immune disease autoindian disease so basically uh what this leflonomy does what is left
Lunomite does look at it here it inhibits the proliferation of the stimulated lymphocytes so it inhibits the proliferation of stimulated lymphocytes something to do with lymphocyte here so basically it also uh decreases the antibody production by b cells so humeral immunity is low here we lose because stimulated lymphocytes will be inhibited the proliferation
Will be inhibited so how it works it inhibits the dihydro orate the dehydrogenase and pyrimidine synthesis actually this is something to do with pyrimidine synthesis till now whatever we saw where purine synthesis if you remember methotrexate and azathioprine all of them were pyrimidine sorry purine inhibitors these are all pyrimidine synthesis inhibitors
Left fluoride is acting on the pyrimidines something to do with the pyrimidines so basically what else you should know here we are not going into very detail about left lunomite um it is given like this orally only so adverse effects will even have all the diarrhea nausea all that because of gi right gi side effects okay so other than this lepleunite you can
Use methotrexate azathioprine etc okay guys so let us meet in the next video bye bye just one thing you note here this dmard are also called as saard because they are very slow at things because it takes like four weeks it seems four weeks to right just to give some impact bro so they can kind of act called as slow acting just all of them are slow acting only
Methotrexate azathioprime all of these are slow acting only okay so we’ll meet you in the next video okay say bye
Transcribed from video
Pharmacology 242 d Leflunomide DMARD Rheumatoid arthritis immunomodulator Pyrimidine By MBBS VPASS
