Non-steroidal anti-inflammatory drugs phospholipids of the cell membrane are degraded by phospholipase a enzyme to produce arachidonic acid arachidonic acid czar metabolized by cox-1 and cox-2 i saw enzymes into eicosanoids i colonize constitute large families of inflammatory intermediates such as prostaglandins thromboxane and leukotrienes aspirin the acetylsalicylic
Acid is a non-selective inhibitor of both cox-1 and cox-2 it irreversibly as it relates the active sites of cooks i so enzymes therefore it suppresses the production of eicosanoid inflammatory mediators hence aspirin is a member of a large family called non-steroidal anti-inflammatory drugs which is abbreviated as nsaids other famous drugs of nsaids family include
Ibuprofen indomethacin naproxen and diclofenac however unlike aspirin all other nsaids are reversible inhibitors of cox iso enzymes you there is a subfamily of nsaids called kooks to selective inhibitors as it is clear from its name this group of drugs is more selective inhibitors of cox-2 but why simply to avoid in the inhibition of prostaglandin e2 produced
By cooks one prostaglandin e2 suppresses gastric acid secretions therefore protects gastric mucosa example of those selective cox-2 inhibitors as silicic sub you
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Nonsteroidal Ant Inflammatory Drugs-nsaids By Pharmacology Animation
