Loop diuretics like furosemide, torsemide and bumetanide produce various side effects ranging from dry mouth to ototoxicity which can be remembered in easy way. Here in this video we will discuss what are adverse effects and how they can be memorized.
Hi everyone today in this video we are going to discuss about side effects of loop diuretics in easy way what are the loop diuretics we have the drugs such as furosemide torsimite which are ending with the suffix semite similarly other drugs like bumatonate which is a end the loop diuretic with mn group at the third portion on the benzoic acid and the third
Loop diuretic is the etherclinic acid which is a phenoxy acetic acid derivative so these are the loop diabetics which are also called as high ceiling diuretics these drugs are indicated in the treatment of severe to heart failure or any other conditions which are associated with edema and in order to reduce the blood pressure in the severe hypertension again
These drugs can be used but these loop diabetes can affect renal functionality and they can increase the excretion of electrolytes and they can also affect the air resulting in hearing loss similarly they can also affect few of the joints by increasing the uric acid levels so today in this video we are going to discuss what are the different side effects of loop
Diabetics and how they can be remembered in easy way first of all let us see the mechanism of loop diatics loop dietics are acting on thin ascending looper henle so the electrolytes like sodium potassium and chloride they are going to be absorbed into the systemic circulation through one of the pump sodium potassium two chloride exchange pump so this is importer
Where one molecule of sodium and one molecule of potassium and two molecules of chloride ions are going to be co-transported now the sodium and potassium can be entered into the systemic circulation by another pump on the basal lateral membrane sodium potassium etiphase pump through this pump sodium and potassium can be exchanged and the potassium can be recycled
By another pump potassium chloride symport in this way sodium as well as chloride are reabsorbed into the systemic circulation by sodium potassium two chloride sympot on apical membrane loop dietics are going to inhibit the sperm so that sodium as well as chloride are not reabsorbed and they are excreted within the urine in this way loop diabetes can affect the
Excretion of many of the minerals which produce various types of side effects now the side effects of loop diabetes can be remembered in a simple way loop diets produce all hypos except on the uric acid levels so these drugs can produce hypo conditions such as hyponatremia loss of sodium hypocalcemia loss of calcium hypokalemia loss of potassium hypochloremia
Loss of chlorine hypomagnesemia loss of magnesium hypovolemia loss of water with loss of body volume so all these hypoconditions are produced by loop diatics except the uric acid where these diets produce hyperuricemia increased uric acid levels within the serum now these side effects can be remembered with a simple code hypo doubt the hyper indicates all hypos
Just we have seen and the letters in the doubt indicates the different side effects produced by loop diatics the letter d can be remembered as dry mouth os autotoxity u as uric acid levels b as blood vision and t as tiredness so hypo doubt are the side effects produced by loop dietics hypo indicates all the hypoconditions produced by loop biotics by increasing
The excretion of many of the minerals and other side effects can be remembered without any doubt as doubt so now let us go one by one first one hypo side effects loop diets can increase the excretion of many of the minerals not only the cations anions are also excreted so they can reduce serum sodium levels they can reduce calcium levels they can reduce potassium
Levels they can reduce magnesium levels and they can also reduce the anions such as chloride ions are also reduced they can reduce the water levels by all of these effects loop diets can reduce the blood pressure resulting in hypotension so hyper side effects also include hypotension where they reduce the blood pressure that’s why these drugs can be used in the
Treatment of severe hypertension and because of this hypotension these ducts can also produce headache due to cerebral vasodilation and they can also produce some drowsiness resulting in fainting sensation these are the related side effects associated with these hypo side effects second one is a dry mop just we have seen that loop diatics can affect the renal
Functionality and they can increase the excretion of fear of the minerals but not only the minerals the water is also more excreted so due to more excretion of water loop diatics can produce some dry mouth in the patients third one is a water toxicity this is a non-renal side effect produced by loop dietics these drugs can block sodium potassium two chloride
Exchange pump within the inner ear which may result in the water toxicity leading to few of the symptoms such as vertigo tinnitus some budging noise within the ear as well as if it is untreated it may also lead to some hearing loss within the patients that’s why these root diets should be carefully given with other drugs such as aminoglycoside antibiotics which
Also produce again autotoxicity fourth one is the increased uric acid limits loop diets produce all hypo except the uric acid where they produce hyperuricemia now at the renal tubules uric acid can enter into the filtrate through one of the transporter o81 as well as four these are the organic acid transporters uric acid can enter into the renal tubules through
The exchange of dicarboxylic acid through this transporter now loop diatics are going to inhibit oat 1 as well as 4 so that they can inhibit the transport of uric acid into the filtrate now when this uric acid is not entering into the filtrate it is more retained within the serum similarly other transporters are present at the apical membrane such as npt4 which is
Again blocked by loop diatics so that uric acid is not secreted into the filtrate this results in hyperuricemia which may increase the risk of gout in the patients fifth one is a blood vision loop diets can increase the excretion of electrolytes so that they can produce dehydration due to loss of electrolytes so these decks can produce some blood vision within
The patients sixth one is the tiredness loop diatics can reduce the serum levels of potassium as well as other minerals potassium is important for muscle functionality so when the potash levels are reduced it increases the muscle weakness as well as some tiredness in the patients so these are the various side effects produced by loop dietics which can be
Remembered with a simple phrase hypo doubt hyperindicates all the hypos such as hyponatremia hypocalcemia hypokalemia hypomagnesemia hypochloremia and hypovolemia all these conditions can produce another hypo effect hypotension this hypotension leads to headache drowsiness and fainting sensation within the patients so which can be remembered with a simple phrase
Hypo similarly the phrase doubt can be remembered in this way they indicates dry mouth or indicates water toxicity u indicates increased uric acid levels b indicates blood vision and t as tiredness in this way we can remember the side effects of loop diets in easy way apart from these side effects loop diets can also produce some allergic skin reactions and you
Can also elevate the glucose levels resulting in hyperglycemia as few other side effects so that’s about the side effects of root dietics hope you have enjoyed this video if you like this video please subscribe to our channel share this video with your friends post your thumbs in the comment box thank you for watching this video
Transcribed from video
Loop diuretics side effects in easy way | Furosemide, bumetanide, torsemide By egpat
