Latanoprost is a prostaglandin F2 alpha analogue used for the treatment of open angle glaucoma (OAG) and ocular hypertension. This drug increases drainage of aqueous humor by which it reduces intraocular pressure in the eye.
Hi everyone today in this video we are going to discuss about later now prost what is this dragged later now past so later no plastic is a prostaglandin f2 alpha analog here we can identify the suffix as low prost where the prost indicates is a prostaglandin and o indicates it is opthalming so laternoprust is an ophthalmic prostaglandin we have few of the
Drugs with similar suffix such as beamatoprost travoprost all these are having the suffix operas and they are used for ophthalmic purpose but we have and the drug carboprost even it is having hanger suffix operas but this drug is not used for ophthalmic purpose this drug carboprost is used to prevent postpartum hemorrhage in the patients so with the exception
Of carbocrast the other drugs latino prost bimtoprost and travoprost all these are ophthalmic prostaglandins used in the treatment of glaucoma so today in this video we are going to discuss about this latino prost how this drug acts what are the important precautions side effects clinical uses we will discuss in this video now what is the use of this latin or
Prost since this is an ophthalmic prostaglandin this diet can be used in the treatment of open angle glaucoma ohg in this open angle glaucoma the intraocular pressure is going to be raised greater than 21 millimeter of mercury which results in some reduced vision blurred vision some blind spots in the peripheral vision and nausea can be observed in the patients
So in such conditions latino process can be given which reduce intraocular pressure by increase the drainage of aqueous humor similarly this can also be indicated in the treatment of ocular hypertension where the intraocular pressure is going to be raised within the anterior chamber of the eye and again iop is greater than 21 millimeter of mercury resulting in
Some eye pain blood vision and if it is untreated it can lead to the some law sufficient so these two conditions which are associated with raised intraocular pressure can be treated by latino prost as this drug is going to increase the drainage of aqueous humor thereby reduce the intraocular pressure now let us see the chemical nature of this triangle so this is a
Structure of latent oppressed and here we can identify the o h groups at ninth and eleventh position which indicates that it is a prostaglandin f two n log and this drug is available as a pro drag and here we can identify an ester functionality this is nothing but isopropyl ester when this isopropyl ester is hydrolyzed it gives the free acid which acts as active
Metabolite so latinoplasty is a prodrag which is converted into later no prostic acid now let us see how this drug acts so within the eye this is the ciliary muscle which is going to connect with the lens through the suspending ligaments now under normal conditions the ciliary muscle can secrete the aqueous tumor which is responsible for lubrication of the lens
But this aqueous humor should be drained in order to control the pressure within the eye now here we can observe the trabecular meshwork which is connected with a canal that is nothing but canal of sclem through which aqueous tumor can be drained out of the eye now under normal conditions this aqueous tumor can be drained through the canal of slam but when the
Lens is going to bulge the iris is going to move which may block this drainage but still this aqueous humor can drain through this canal of slam sometimes this drainage pathway is going to be blocked which produce narrow angle glaucoma but in the open angle glaucoma the lens is normal and iris is not blocking the pathway of aqueous humor but still there is a
Block in the trabecular meshwork which results in the decreased drainage of the aqueous tumor in such conditions latinoplast can be given which can act on the fp receptors which are expressed on the epithelium of ciliary muscle now let no pros can bind to these fp receptors which results in the increased flow of aqueous humor so aqua tumor can be more drained
Through the canal of slam so as the aqua humor is drained out the intraocular pressure is going to be reduced resulting in the relief from glaucoma as well as ocular hypertension what are the precautions one of the important precaution of latino plastic is related with the eye this dye can produce iris pigmentation so suppose this is the normal iris which is
Having no pigmentation but melanin is one of the pigment which can be deposited in this iris by the use of latent or prost the melanine deposits can be slowly accumulated within the iris and if it is not controlled it can produce a complete pigmentation of the eyelids but this is a reversible side effect that can be observed with the latent of rust whenever the
Drug is going to be stopped again the pigmentation can be reduced but care should be taken in order to monitor any pigmentation of the iris after use of latin or prost similarly this dye can produce eyelash changes so this is the normal eye but after use of latino prost it can increase the length of eyelashes so the length of eyelash may be increased even the
Thickness of eyelashes can be increased and this can also increase the pigmentation of the eyelids so melon pigmentation can be increased on the eyelid and uneven growth of eyelashes can also be observed with this lateral past fortunately again this side effect is reversible so whenever this drug is going to be stopped these effects can be minimized similarly
Latino process can also increase the intraocular inflammation so within the eye can produce inflammation resulting in the redness of the cornea so it can produce some iritis uveitis so care should be taken to monitor any inflammation within the anterior chamber of the eye and it can also produce some macular edema the swelling of the macula and finally it cannot
Produce viral infections such as hepatic keratitis which is produced by herpes simplex infection now let us see the side effects of phletonuprost many of these side effects are related to the local side effects so it can produce stinging after the administration of eye drops burning sensation some itching foreign body sensation within the eye it can also produce
Some blood vision and iris pigmentation apart from these local side effects we can also observe eyelid pain eyelid erythema swelling of the eyelids some increased tearing and systemic side effects such as muscle pain respiratory tract infections such as cold or influenza and hypersensitive reactions like skin dashes can be observed with this latino prost how it
Is given this drug is given as ophthalmic solution at a strength of 50 microgram per ml and this drug should be administered to the eye one drop in eye once daily in the evening so that’s about this latino prost which is a prostaglandin f2 alpha analog which is an ophthalmic prostaglandin analog so we can easily identify the suffix operost which indicates this
Diet is used for ophthalmic purpose we have similar drugs like bimitopras travoprost but carboprost even having the suffix oprost it is not used for ophthalmic purpose it is used to prevent postpartum hemorrhage after the delivery electroplast is a pro drug and it is available as ester form which is hydrolyzed in vivo to produce later of prostatic acid which is
The active metabolite and this drug can act on the fp receptors expressed on epithelium of ciliary muscle which increase the drainage of aqueous humor this document you produce irish pigmentation increased growth of eyelashes increased thickness pigmentation of the eyelids so case should be taken to monitor these changes which are again reversible and they can
Be restored after stopping of the drag and this that can also produce intraocular inflammation macular edema and even hepa simplex infection in the eye this reproduce local side effects such as stinging burning itching redness of the eye and blood vision and this drug is available as ophthalmic solution which should be administered as one drop into the eye once
Daily in the evening and this drug is contraindicated in hypersensitive reactions and it can show some drug interaction with few of the preservatives like the thiomersol so case should be taken not to mix other eye drop medications with this of rast so that’s about this drag hope you have enjoyed this video if you like this video please subscribe to our channel
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Transcribed from video
Latanoprost – Mechanism, precautions, side effects & uses By egpat
