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Hello and welcome to the medical journal club your daily dose of health and medical news i am dr b b rahul and here is what we have for you all from the world of medicine maternal tenofovir along with vaccination may prevent vertical transmission of hepatitis b in babies a combination of hepatitis b vaccination and immunoglobulin is the cornerstone of vertical
Transmission prevention for women who are positive for both hepatitis b surface and envelope antigen says an article published in american journal of obstetrics and gynecology this study was carried out by hearty and gwen and colleagues to examine the efficacy and safety of pharmaceutical therapies to prevent vertical transmission of hepatitis b virus cochrane
Medline and scopus database were searched for this study up to october 28 2020. the randomized control studies that reported vertical hepatitis b viral transmission with pharmaceutical intervention were properly searched and included in the analysis cochrane risk of biostool version 2 was used to assess the risk of bias the effectiveness of the treatment was
Calculated using a stratified network meta-analysis which was based on maternal hepatitis b envelope antigen status the result of this study stated as follows there were 19 studies that involves moms and tested positive for hepatitis b surface and envelope antigens the combination of hepatitis b vaccination and immunoglobulin in babies lowered transmission risk
Much more than the vaccine alone with a risk ratio of 0.52 with a pooled risk ratio of 0.10 only the inclusion of maternal tenofovir diesoproxyl fumarate but not delby wooden lamy wooden or maternal hepatitis b immunoglobulin further lowered the transmission risk in the newborn compared to a combination of hepatitis b vaccination and hepatitis b immunoglobulin 12
Studies in mothers with hepatitis b surface antigen positivity but mixed unknown or negative hepatitis b envelope antigen status provided limited evidence that maternal hepatitis b immunoglobulin combined with hepatitis b vaccine and immunoglobulin in infants was likely best treatment but this failed to reach statistical significance when compared to combination
Of hepatitis b vaccine and immunoglobulins in infants similarly adding newborn hepatitis b immunoglobulin to immunization gives potential extra benefit but fails to attain statistical significance in conclusion the inclusion of maternal tenophobe to this newborn combination regimen was thought to be most probable successful therapy no further agents offered
Extra benefit beyond this hepatitis b vaccination alone for newborns of women with hepatitis b surface antigen positivity and mixed unknown or negative hepatitis b envelope antigen status that’s all for today stay tuned to medical dialogues for latest updates never miss a medical update from medical dialogues like subscribe and press the bell icon
Transcribed from video
Journal Club Maternal tenofovir along with Vaccination may prevent Vertical Hepatitis B transmission By Medical Dialogues
