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Hi everyone welcome to researchmd.com so today we got a great presentation today we’re going to talk i mean we’re going to look into how much melatonin we needed to look for a better sugar control in patients with the diabetes we’ve been doing series of melatonin right uh we looked at the mechanism of action how does melatonin work so in now i mean today’s presentation
We’re going to look at on a scientific basis okay how much melatonin is beneficial to control the blood sugar in diabetes patient um so my again my name is premier chariot i’m a program director internal medicine residency transitional residency i teach medical students and medical residents i’m also director of research approach from medicine to major universities
So let’s get into our subject and this introduction of melatonin um where does it produce it’s actually produced in the pineal gland so you got luminous information coming from the retina when we become actually it happens in the dark and then it’s secreted go through the suprachiasmatic nucleus in the um hypothalamus and then it goes to the pineal gland in the
Brain and then starts secreting melatonin okay now pathogenesis so what happens in the diabetes in the diabetes the main thing is the abnormal insulin sensitivity okay which will lead to hyperinsulinemia central obesity progressive losses of beta cell that’s pretty much where the insulin and oil are produced impaired glucose tolerance which lead to diabetes it
Could be some genetic factors could be a physical enacting activity and high blood glucose a lot of things contributing into it right so how does the melatonin help in diabetes melatonin in the diabetes what happens is the melatonin act on the insulin receptor tyrosine phosphorylation and thereby it increases the ige for insulin growth factor production okay and
That when you have increased insulin then you have like a better blood sugar control and the other thing is also the main thing um not main thing some of the reasons for having diabetes is or you have this altered circadian rhythm or the body’s 24-hour clock is usually kind of messed up your um eating cycle and this uh the fasting cycle is going to be disorganized
That all leads to like many hormones and your blood sugar level depends upon that okay so melatonin restores your body’s 24-hour clock or circadian rhythm they reset it which everybody knows that right and also melatonin there’s so many ways melatonin can affect us we know it increase the metabolism what happens when we increase our metabolism our weight goes
Down again blood sugar everybody knows that if you lose weight you get a better control of blood sugar right and it induces the insulin secretion signaling pathways so better production of insulin and improve the beta cell function so it improved the production of insulin again so our question today is how much melatonin needed per day um to have a good control
In diabetes management okay so we did do a meta-analysis or study does melatonin works in blood sugar control right that study clearly showed melatonin also as an effect in the blood sugar control in that study also it said there is like a low dose and high dose there’s a big difference you can see um from this study okay so what we did is we went back to the
Study and found a best randomized control study and it was published in the clinical nutrition and then we just kind of went in there to find out how much though they used to get the effect okay so in that study based on the results say fasting blood glucose level melatonin if you take 10 milligram melatonin and they compared it there’s a big difference and with
A i mean a statistically proven benefit of blood sugar control okay so melatonin 10 milligram based on the study is better for a better control of glucose level in diabetes patient so in our in based on our literature search and looking at the scientific article higher dose of melatonin which is 10 milligram helps with better blood sugar control okay thank you
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Transcribed from video
HOW MUCH MELATONIN IS NEEDED IN BLOOD SUGAR CONTROL IN DIABETIC PATIENTS? – Dr. Pramil Cheriyath MD By ResearchMD
