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Terazosin and tamsulosin, in patients with benign prostatic hyperplasia. but, how do they provide benefits in this condition? let’s see. and needless to say, a normal person, does not have difficulty in micturition. now, in benign prostatic hyperplasia, the prostate gland enlarges. this obstructs the flow of urine.
Urinary hesitancy, narrowing of the stream, next, the smooth muscles in the prostate, and at the base of the bladder, have α1 type of receptors, is to increase the tone of the smooth muscle. or in simple words, they cause contraction. normally, this is useful in holding now, although the problem is not with
The and we can do so with α blockers. when we give α blocking agents, the activity of the α1 receptors of the prostate, and bladder base, decreases. urination-related symptoms that we discussed earlier. blockers are preferred, like terazosin, doxazosin, alfuzosin, tamsulosin etc. apart from α
Blocking activity, terazosin and doxazosin, also induce apoptosis in the prostate. so they provide an additional benefit, of reducing prostate size. i also want to provide some additional benefit. this subtype, is thought to be the one present in the prostate, and bladder base. so tamsulosin has more selective action
On the prostate and bladder, and fewer effects on other organs. so it has fewer side effects, as compared to other α blockers. so this was a detailed explanation. relaxing prostate and bladder base smooth muscles, that’s it for this video. you can find the notes website. the links are in the description.
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Transcribed from video
How Alpha Blockers Help in Benign Prostatic Hyperplasia? By Nonstop Neuron
