Immunosuppressants are diverse groups of agents that halt immune system at different stages.
Immunosuppressants you antigen-presenting cells bind to t-cell receptors and activate them this activation results in a cascade of reactions that end in the release of intracellular calcium ions the released calcium ions bind to and activate calcineurin enzymes which is a calcium dependent phosphatase active calcineurin dephosphorylates the inactive nuclear factor
Of activated t cell which is abbreviated as in fat this phosphorylation process activates in fat which in turn travels into the nucleus to promote the transcription of interleukin 2 cytokines interleukin-2 mrna moves to the cytoplasmic ribosome where interleukin 2 cytokines are produced interlaken two molecules are released from t cells and response to different
Stimuli to start a new cascade of cell mediated immunity interleukin-2 binds to and activates transmembrane receptors at t-cells this activation process initiates a cascade of reactions that result in the activation of mammalian target of rapamycin also known as mtor the active mtor in turn regulates important intracellular pathways that promote cell growth and
Proliferation generally immunosuppressants can interfere with different stages of the cell mediated immune system for example cyclosporine can traverse the cell membrane and bind to specific intracellular receptors called cyclo fillings cyclosporine cyclo fillion complex and burn bias – and inactivates calcineurin enzymes therefore they inhibit the production of
New interleukin-2 molecules similarly sirolimus drug binds to intracellular binding proteins called fk bp the sir alamos if kbp conflicts interferes with the function of mtor therefore they suppress the proliferative effects of interleukin 2 cytokines you
Transcribed from video
General Immunosuppressants animation video By Pharmacology Animation