Four month Moxifloxacin-Based regimens for Drug-sensitive tuberculosis.
He actually is a common problem which describes having an infection in the lungs pb % but if we classified it simply it’s a bacteria were in close to the part of the valley where there is a lack of blood and a lack of oxygen so basically meaning tv goes to the lungs % there’s a lack of supply of blood and oxygen and that part categorically tbs is an infection
We’re in a patient with develop chronic cough and it can actually cause structural problems to salons the problem with this tv we compared to other diseases is tvs actually very good in juice but the problem of being this this disease people davis is that how this disease is actually spread person-to-person my problem so tv is actually an infection that is
Common among people in overcrowded areas and we follow you what are the symptoms of tuberculosis it is a pleural effusion collection of fluid between the lung and chest wall the symptoms include off chest pain shortness of breath fever sweating at night poor appetite weight loss you so there is a great need for shorter duration tuberculosis treatments why
Because the tuberculosis treatment right now the shortest standard treatment for tuberculosis is six months six months involving four drugs the four drugs used for treating tuberculosis are p reason ameed a fam with all eyes on eyes it and refampin so for drugs given according to a specified schedule which is similar throughout the world there’s a problem with
This treatment it’s too long six months is a long time and many people drop out with the treatment and known don’t end up being cured so there’s a great research effort in finding shorter duration treatments it was recently found that moxifloxacin which is a an antibiotic belonging to the class of plural quinolones as it has been shown that it has great activity
Against mycobacterium tuberculosis so therefore it’s hypothesized that by incorporating moxifloxacin into the standard treatment by replacing one of the drugs used will lead to shorter but still effective treatments so this study aims to prove this whether moxifloxacin could help establish shorter duration treatments for tb and the study involved 1931 patients
Divided into three groups one group received the standard tb treatment with the four drugs peer as enemy defend with all rifampin and isoniazid according to the standard schedule and the treatment lasted for six months the second group involved giving moxifloxacin instead of eyes on eyes it so they received the standard treatment but eyes on eyes it was replaced
By moxifloxacin and the duration of treatment was four months group three involved replacing multi foxes in so giving moxifloxacin instead of ottumwa talk so the four drugs were given but it them both all was replaced with moxifloxacin also for four months the results of this study or as follows so group one had a treatment success rate so a cure in 92% of the
Cases so the standard treatment was successful in 92% of the cases in group two which received moxifloxacin instead of isoniazid this is success rate was 85 percent in the third group who received moxifloxacin instead of pithom with all the success rate was 80 percent so these results showed that unfortunately moxifloxacin given in a shorter schedule for only
Four months was not as effective as the standard treatment which lasts six months so this is a major setback because there was high hopes there were high hopes that this new treatment would moxifloxacin would lead to a faster cure but unfortunately there’s a need for more research more drugs need to be tested perhaps we need new drug targets so the the matter of
Shorter duration treatments for tuberculosis is still open and new research is eagerly awaited
Transcribed from video
Four month Moxifloxacin-Based regimens for Drug-sensitive tuberculosis. By Andrea Carolina Jaramillo Bajaña
