Formoterol is a Long acting beta2 adrenergic receptor agonist (LABA) indicated either alone or in combination with other drugs such as Inhalation corticosteroids (ICS) or anticholinergics.
Hi everyone today in this video let us discuss for moteral what is this drug for motival from the name of this track we can find some interesting information we can remember if you have the information in easy way for instance the first three letters for can be remembered as far so this drug is having some long duration of action so far motorola is a long acting
Drag and the suffix sterol indicates this truck belongs to a group of drugs ending with similar suffix for instance all butyrol which is also called as sulbutamol and salt material all these drugs are having a similar suffix terror so these drugs are acting on the beta to adrenergic receptors acting on the bronchioles so they are acting like bronchodilators
But even all these drugs are ending with similar suffix their duration of action is not equal albuterol is a short acting beta to aegonist so it is commonly known as saba shot acting beta-2 eternal chickagonist whereas salmeterol is classified as lava long acting beta two international next now here for motorola is also a long acting track which is classified as
Lava we can also remember the side effects of formatorol from the name of this drug just we have seen that the prefix fur can be remembered as four so this trick is long acting beta two agonist the letter m can be remembered as muscle cramps so this truck produce some muscle cramps as one of the important side effects and woh can be remembered as hypokalemia so
Potassium levels are reduced which produce hypokalemia resulting in the muscle cramps the letter tree can be remembered as tremor so one of the important side effect of formatrol is the tremor as this drug is going to increase the muscle twitching the letter e can be remembered as exacerbation even pharma troll is a bronchodilator it can increase the bronchospasm
So on long term use format formotrol can also increase the bronchospasm so even it is a paradoxical effect exacerbation of bronchospasm particularly in the patient with copd chronic object to pulmonary disorder can be observed with long-term use of for material and finally the letter r can be remembered as rapid heartbeat so farmetrol can increase the heartbeat
Resulting in the palpitations and tachycardia in this way we can remember if you have the important side effects of format role with simple quotes m indicates muscle cramps who indicates hypokalemia t indicates tremor indicates exacerbation of bronchospasm and or indicates rapid heartbeat prefix for indicates is a for acting so it’s a long acting beta to echo
Next actually the form at all the prefix form indicates that this is having a pharma mind moiety being a beta to energy agonist this drug is having some structural similarity with the catecholamines so catecholamines are having the o h group at third and fourth portion of benzene ring now this o h group is going to be replaced with the pharmamide informational
Long-acting beta-2 energy economists can be combined with other category of drugs such as ics just we have seen that far motorola is a long-acting beta-2 economist so this can be combined with inhalation corticosteroids such as buddhisonite bactlomitzone fluticasone cyclusinide any of the steroids can be combined with the formatterol and they can be formulated in
Different doses forms for instance this combination can be prepared as inhaler in this inhaler both for motorol and ics are going to be combined which are going to be administered into the mouth through the inhaler why this combination is going to be used in this combination for motorola is a long acting beta to agonist so it can act on the bronchioles to produce
A bronchodilation on the other hand inhalation corticosteroids can reduce the recurrence of bronchospasm so in the patients with any asthma and copd these inhalation corticosteroids can reduce the recurrence thereby they can be used as preventive medication so they can reduce the attacks of asthma and severe bronchospasm the formatorol can also be combined with
Other categories of drugs such as anticholinergics if you have the drugs like triotropium glycopyrolate these drugs can be combined with the formation all and they can be given either as capsules or inhalers all these are indicated by inhalation root both of these drugs are acting on the bronchioles but in a different way the format role is going to activate
The beta to adrenergic receptors whereas anticholerics are going to block the m3 receptors so far motorola is agonist and anticholinergics are the antagonists but the result is same both of these drugs are going to produce a bronchodilation and particularly this combination is more useful in the treatment of copd chronic obstructive pulmonary disorder where
Anticholinergic show more efficacy in the treatment for motorola alone is also available it is available as capsules which are taken by inhalation root by using rota heller which is opening the capsule where the medicine is going to be inhaled directly into the lungs they also available as solutions which is intended for nebulization but nowadays for motorola is
More preferred in combination with other drugs such as inhalation corticosteroids or anticholinergics now that is the chemical nature of this type so this is the structure of formative role we can clearly observe that it is having the pharmamide moiety so far motorola is a pharmamide derivative of catecholamines now let’s see how this drug acts on the bronchial
Smooth muscle beta-2 adrenergic receptors are present which are g protein-coupled receptors they are coupled with alpha beta-gamma subunits now pharma troll acts as a long-acting beta to adrenergic agonist this drug is having a duration of action of around 12 hours so it can be given twice daily and this format all can estimate these beta2 receptors resulting in
The activation of adrenal cyclase system this adrenal cyclase when it is activated it can convert the atp into one of the secondary messenger cyclic amp now cyclic amp plays an important role in the smooth muscle in the heart it is responsible for contraction but within the smooth muscle it is responsible for relaxation of the smooth muscle this cyclicamp can
Phosphorylate one of the important enzyme mlck myosin light chain kinases this myosin light chain kinases are going to be converted to myosin light chain phosphate which is the inactive form of this enzyme in this way the activity of mlck is going to be reduced by cyclic amp this mlc is required for phosphorylation of myosin light chains so myosin light chain
Phosphates are not formed due to inactivation of mlck so when this myosin light chain phosphates are not formed the contractile mechanism is inhibited resulting in the relaxation of the smooth muscle in this way formatrol acts as bronchodilator but this drug is having long duration of action what are the precautions one of the important precaution is that the
Pharma troll should not be given for acute exacerbations of copd so for acute bronchospasm this format really is not that much useful in such condition this target somewhat ineffective and it should be treated by short acting beta to iguanase similarly this drug can stimulate the beta-2 receptors located on the smooth muscle resulting in the increased muscle
Twitching leading to tremor in the patients even this drug is more selective towards the beta2 receptors it can also act on beta-1 receptors so far motorola can stimulate the beta receptors located on the heart resulting in the palpitations tachycardia even it can produce some chest pain so in the patients with any angina or tachycardia and other cardiovascular
Disorders this drug should be carefully given pharma troll can also reduce the serum potassium levels resulting in the hypokalemia which increase the muscle cramps so again care should be taken with other drugs which again produce hypokalemia similarly this drug can increase the glucose levels resulting in the hyperglycemia this action may be attributed to
Increased glucose production within the liver by activation of beta-2 receptors so pharmatrol can produce hyperglycemia so in the diabetic patients this stretch should be carefully given what are the side effects the important side effects mainly include tremor dizziness insomnia palpitations dry mouth some leg cramps can be observed hypotension because they
Produce vasodilation hypokalemia hyperglycemia can be observed and it can also produce some allergic reactions and rashes can be observed with this pharmaceutical so that’s about this drug pharma troll which is a long-acting beta-2 agonist if you have the information of this drug can be remembered in easy way the prefix form indicates that it is a for-acting it’s
Having long duration of action and it is classified as long-acting beta-2 economist and the letter m indicates it produce muscle cramps o can be remembered as hypokalemia t can be remembered as tremors e can be remembered as exaggeration of bronchospasm or can be remembered as rapid heartbeats so with this we can remember the side effects and drug information of
Format it all in easy way so that’s for today hope you have enjoyed this video if you like this video please subscribe to our channel share this video with your friends post your comments in the comment box thank you for watching this video
Transcribed from video
Formoterol for Asthma & COPD | Combinations & side effects in easy way By egpat
