lost some of the footage. my bad for the beginning of the video
Yeah and i stumble on uh from motorola which was a which is also a beta2 um receptor agonist and the reason why i didn’t like klein bureau was as you guys know it has a lot of cardiac related side effects which is due to the fact that it didn’t selectively agonize the beta 1 receptor for reference beta1 receptors are mostly present in the heart and people use
Um some meds like nabivillo or many other or propranolol to actually again antagonize the receptor and colombial actually agonizes it a bit weak weekly but that’s that’s not good enough um so that’s why i i found this this compound which is um which has really interesting really really interesting uh data behind it um this video i’m gonna be sharing a bit
Of the research i’ve done i could make a longer video but i i’m i’m not really fond of like watching long videos and pretty boring um if one was the citations for these um um studies i can link it to you uh one of the first studies that i like to share it’s only 2020 uh study which is uh in the journal of neurobiology of disease this was a really interesting
Study because basically they found that it um it reverses the effects of tbi which is the traumatic brain injury and one of the effects of a traumatic brain injury was mitochondrial dysfunction mitochondrial dysfunction mitochondria is present in most of the cells and has many uh functions and when mitochondrial dysfunction happens it’s one of the like the
Big signs of aging one of the big signs of aging and so this was shown to be um to be able to actually induce something called mitochondrial biogenesis mitochondrial biogenesis is basically the just the reorganization of mitochondria and the birth of mitochondria which is really which is really good people do people how people i guess trigger mitochondrial
Biogenesis by fasting specifically prolonged fasting and autophagy and like a whole slew of things to trigger it but this is um a really interesting a bit like it’s a side tangent when i’m not it’s not that fat burning aspect but um i like this aspect of it it’s uh it’s really really interesting so now i’ll get to some of the the nitty-gritty of this so in this
Study you talked about the lipolytic and anabolic lipoic is basically the comes from the word lipolysis or like political activity which is basically the um when you burn adipose tissue the breakdown of adipose tissue into the bloodstream into glycerides and glycerol and fatty and free-form fatty acids and here we they talked about from from meteorol a bit uh
And compared it to other rarely available beta-2 um agonists and um so this is clam bureau which is fairly used in the bodybuilding space um and they compare it to all kinds of other ones salbutamol is also one of the ones that’s also used in the bodybuilding space so it’s compared to from italia again and if you guys can see the beta2 adwords adreno receptor
Selective selectivity effect efficacy between the columbia raw and from metro for motorola and clan bureau doesn’t have the best selectivity compared to this which has very high selectivity which is besides salmeterol um it’s really good compared to anything else in this class of uh drugs um so let me get into some of the um the anabolic and androgenic sorry
The anabolic and lipolytic activity of it so so let me talk about brown fast brown fat adipose tissue thermogenesis so brown fat is so they thought at first that brown fat was only present in children brownfield is basically my mitochondria rich adipose tissue and one of its main functions is thermogenesis um when you’re cold you you activate brown fat and
You get warmer so it’s realized that beta 3 receptors are one of the ways that you can activate brown fat um and they did a study by using this rock i used this thing mere big one it’s basically beta 3 receptors are present in many things one of them is the bladder so when someone has an overactive bladder they give them this prescribing this medicine and i try
This thing not because they have an overactive bladder but it to i guess stimulate some brown fat thermogenesis and it sucked um i couldn’t pee if i try to pee it burns i don’t like it i don’t recommend it at all um so in the study we actually theorized that beta 3 or sorry beta 2 activation stimulation is one of the ways to stimulate brown fat thermogenesis
And it actually found that when they knock the um the activity of beta2 receptors in rodents that it actually impaired the brown fat thermogenesis so that’s something that i find really interesting because um when i use for metal there is actually a slight amount of um i guess warmth that you feel sometimes with dnp but it’s not to that extent if you guys
Didn’t know dnp is also uh also stimulates brown fat thermogenesis with a slew of other things but i don’t recommend using dmp so let me get to the human study this is a human study induces gender dimorphic whole body leucine metabolism humans gender myomorphic means um applies to two genders oh sorry to both tenders or happens in both genders so they gave them
160 micrograms a day of oral treatment which is almost uh double what i take i usually take 80 80 sorry and 80 micrograms then i titrate to 160 micrograms depending on how like how much i wanna how much you want to burn i guess so without um i’m seeing my obs and i’ve been recording for way too long let me speed it up for you guys so when they gave them 160
Micro micrograms a day this is what um this is um what happened exactly to them so the resting energy expenditure increased from 100 1467 to 1 630 which is almost a 200 calorie difference of uh more energy expenditure their fat oxidation went from 56 to 70. really good that’s like uh 20 actually no it’s less uh i’m not i’m not that good with math uh brown um
I’m sorry uh carbohydrate oxidation went up glucose fasting glucose it’s it’s up but it’s not the best there’s not much of a difference this is really interesting this is the way the the main reason i took i take this thing and not take my budo anymore um heart rate the difference between i take uh for reference i take 80 micrograms and a four four points above
I mean four point difference or increase in heart rate is actually insane if i take clean butyl oil this is probably in the high 80s most likely another thing is blood pressure it’s actually lower and taking this compound that it is in um than it is with the baseline uh this is the numbers for the bronze um sorry for the low c leucine oxidation and leucine
Uptake and also they’re way higher uh in losing um numbers baseline versus 160 micrograms a day um so i’m just making this short video i want more people to take this and try it out because i’m i’ve been taking it for about the past two months and i can tell you the it’s the best possible uh let me think it’s possibly the best fat burner i’ve ever used and i’ve
Used the np t3 t4 uh columbia law walls that i use um i guess you could say l-carnitine is a fat burner as well but this is the best one i’ve taken in both a anabolic and lipolytic activity or fat burning activity so um millions of people take this thing but uh they don’t take it for the exact reason why i’m making this video so i’m just making this video in
Hopes of seeing more people uh try it out and give um give me the we need more data about this because it’s really interesting and i don’t want to see people taking um clan bureau anymore even though there are ways to mitigate climb beautiful cardiac side effects but uh why would i take more drugs to kind of have the effects of my fat burner this is almost as
Good as computer without the slew of side effects so thanks for watching guys
Transcribed from video
Formoterol: a better version of Clenbuterol? By Flickapotamus
