This is an informational overview video about Fluticasone. Fluticasone is a inhaled corticosteroid, that leads to reduced inflammation and bronchodilatation.
Haider welcome to this in-depth video of fluticasone this video will cover everything you need to know how we’re going to use fluticasone what is the correct dose but also what are possible side effects on what interactions does it have with other medications we will cover that and many more in this video i also made it shorter more to the point video that covers
All the essentials and easy to understand language you can find a link to that video in the description furthermore don’t forget to subscribe let’s get into it first a little disclaimer this videos meant purely informational this is not medical advice and always ask a doctor if you’re looking for medical advice so the generic name of this medication is fluticasone
But there’s no known as several brand names like flick so tight bre ellipta or relevant laptop and is available in three forms those areas oles nebulizer or as an inhalation powder and each of these forms have their own indications of use so the dose areas of where the inhalation powder can be used as maintenance treatment of asthma as well as adults and all the
Children but even in young as old it also can be used as maintenance treatment of copd and this is mostly suitable for copd patients with severe complaints so they need to have a first expiratory volume of less than 60 percent of the predicted value and they also need to have repeated accessor bation during the year without treatment then the nebulizer can be used
In the treatment of severe asthma and adults or children older than 60 years and it can also be used in the treatment of an acute exacerbation of asthma and adults and children older than four years old so how does it work fluticasone is an inhaled corticosteroid and it has several effects first it reduces sensitivity of tissue receptors for inflammatory mediators
And branko constructive mediators it also leads to the formation of proteins that inhibit the production and the release of prostaglandins and leukotrienes also inhibits inflammatory the infiltration of limitary cells in your lungs and lastly it inhibits degranulation of mast cells in your lungs and therefore it decreases the level of i ge so what effect us does
Have it improves your lung functions and it also reduces inflammatory effects in your lungs so at least two less accessor basins during the year less bronchial hyper responsiveness and less exercise related bronchial obstructions so that’s a whole lot of good effects then some advice if you want to prescribe fluticasone and asthma always use this three-step approach
The first step is lifestyle interventions stop smoking to enough exercise and weight reduction if necessary this is insufficient someone has more than two times symptoms of asthma a week start a short-acting beta-2 sympatico mimetic this isn’t sufficient and somebody keeps having more than three episodes of asthma a week and you start an inhaled corticosteroid like
Fluticasone and maybe in combination with a long-acting beta – synthetica mimetic if you want to treat a patient for copd again this has four steps first step again lifestyle interventions the second step is short-acting bronchodilators like our petropia m– maybe in combination with a better – synthetica mimetic like so butanol step three will be add a long-acting
Bronchodilator and step four is and haled corticosteroids like fluticasone or long-acting bronchodilators like add vr and this is only suitable for patient who need more than one hospitalization a year through their severe symptoms so how do you use it depends a bit on the indication you always inhale it preferably with an inhalation chamber this way the medication
Spreads more effectively in your lungs after the use always rinse your mouth because it otherwise may lead to fungal infections in your mouth and when you use it for asthma you may have effects within four to seven days after your initial use and you will experience the maximum within several weeks for copd takes a little bit longer within ten days you may be
Experiencing any benefits and the maximum effect is achieved when in three to six months so you need to use it a long time before you notice some results how long can you do this or how long do you need to do this would be the better question probably for a very long time together with your doctor you will make it plan and you build up the medication dose so you
Reduce you the symptoms you are having and you always need to take your medication at fixed times regarding safety there are no restrictions for driving it’s perfectly safe to drive with this medication you can also combine it with little amounts of alcohol and with any type of food so what does should you take if you want to use it as maintenance treatment and
Asthma you’re an adult or a child although that 60 years and you want to use those areas or inhalation powder your initial dose should be 100 micrograms two times a day the maintenance dose is 100 to 500 micrograms two times a day and this is depending on what you what to advise of your doctor is and then the maximum dose in the day would be two thousand micrograms
In case of severe asthma for children from 4 to 16 years the initial dose is 50 micrograms two times a day and the maintenance dose would be fifty two to two hundred micrograms two times a day and for even younger children from one to four years to those areas oles there should be 100 micrograms two times a day you should always use a baby inhaler which is a smaller
Inhaler inhalation chamber this makes it more easier for the young child to inhale the medication then if you want to treat acute asthma exacerbations an adult or children older than 16 years always use a nebulizer you can use five hundred to two thousand micrograms two times a day maximally up to seven days if you still need to use it after seven days always
Contact your doctor to see if other medication is necessary for children from 4 to 16 years you can use to those five hundred two thousand micrograms two times a day again maximally seven days and now lastly if you want to use it for maintenance treatment in copd and adults use 500 micrograms two times a day and available a to use after three to six months to
See if you have sufficient effects unfortunately fluticasone can also have some side effects very commonly more than 10% of all people will have oropharyngeal candidiasis which is a fungal grow in your mouth because you do not reach your mouth properly and therefore you should always do that commonly one to ten percent of our people will have hoarseness bruce’s
Pneumonia or bronchitis mostly in copd patients and an uncommonly less than 1% of our people will having hypersensitive reaction on the skin from the use of inhaled corticosteroids and rarely we see fungal grow in your throat very rarely we see any of these but this is really exceptional i will not name them all feel free to pause the video and if you think you
May be experiencing any of these side effects or maybe now another one always check your prescription and contact your doctor to see if your medication needs to be changed or your dose needs to be adapted so the use of fluticasone also has two interactions with other medications firstly when combined with strong inhibitors sep 3 a for like written of year or each
Raccoonus all this may lead to a strong increase in the fluticasone levels in your blood and therefore may lead to adrenal suppression and we should be very careful for this furthermore when fluticasone is combined with systemic corticosteroids this may lead to hypoglycemia which can also be dangerous so i’ll so take that into consideration for pregnancy politicals
On a safety use will not pass through the placenta and will not be harmful for the baby or the fetus and can be used as prescribed and for lactation which is breastfeeding it’s the same story will not pass through brass milk and therefore is safe to use and can be used up as prescribed there are no relevant contraindications found in the use of fluticasone and
There are some warnings first of all when you see paradoxical bronchospasm or this new year after the use of fluticasone you should always stop the treatment and switch to another inhaled corticosteroid then when you use fluticasone it may lead to an increased risk of pneumonia mostly in copd patients patients therefore you should always ask for the risk factors
In these patients which is smoking older age in history of pneumonia a low bmi and severe copd and when they have any of these risk factors you should be careful and prescribing fluticasone also the use of fluticasone may lead to activation of pulmonary tuberculosis and long term and high – use of fluticasone may lead to systemic effects like cushing’s syndrome
Reduced bone density growth retardation cataract glaucoma of the eyes and psychological or behavioral disorders and this is mostly seen in children or young people like adolescents and my last slide kinetic properties of fluticasone resorption is of course mostly done by lung speaker she inhale it’s the first pass of the inhalation powder is only 8% and of those
Areas is only 11% so it’s not a lot the dividing the lumen is 4.3 liters per kilogram protein binding is 91% which is very good it’s mostly metabolized by liver by sip 3a for enzyme and it takes your body approximately eight hours to half the value of fluticasone in your blood sorry this was my in-depth overview on fluticasone i hope you’ll learn something feel
Free to leave a like and subscribe for more upcoming videos thank you for watching and see you next time
Transcribed from video
Fluticasone (Fluvent, Flixotide, Breo Ellipta): Professional Medical Summary -In Depth By HOW TO MEDICATE
