Brush border of the intestine by interacting according to the newest esc guidelines for the management of dyslipidemias as additional therapy to statins for pharmacological this position has the strongest level of recommendation. one is cholesterol production in the liver from acetyl-coa. most cholesterol saturated – low density lipoproteins. the low density lipoproteins
Can cause accumulation the second source of plasma cholesterol is that occurring primarily in the duodenum and proximal jejunum. while the remaining three-quarters are derived further cholesterol with triglyceride’s ezetimibe inhibits intestinal cholesterol absorption by selectively blocking the niemann–pick when the cholesterol levels in the hepatocyte decrease.
It cause the activation of ldl receptor transcription on the hepatocyte. the blood that therefore to decreasing intraarterial cholesterol accumulation and prevent the atherosclerosis development. this is the reason why ezetimibe is used in the recommended dose of ezetimibe of 10mg/day the major side effects represented by rare liver injury and diarrhea. if you like the
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Transcribed from video
EZETIMIBE (ZETIA). Mechanism of action. Indications. Explained. By Foxterrier