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Ethinyl Estradiol

Posted on October 29, 2022 By
Health

1650167 the topic that is assigned to me is the synthetic form of estrogen this means that it is not the naturally available form of estrogen instead it is a synthetic version of estrogen it should be remembered that eating estradiol is the most commonly used form of estrogen now the indication ethenile easter diol is combined with other drugs for use it means

That it is not used alone instead in combination as a contraceptive for pre-menstrual dysphoric disorders for moderate acne for moderate to severe major motor symptoms of menopause and for the prevention of post-menopausal osteoporosis it should be remembered that for the use of ethynae hysteroidal there is increased risk of thromboembolic disorders breast cancer

Hyperpigmentation migraine endometrial cancer and myocardial infarction its adverse effects include nausea vomiting headache bloating breast tenderness swelling with ankles and feet and feet this is due to fluid retention weight changes may also occur now the itinerary is as you know that it is used as a contraceptive so there are three ways it produces its

Effect it either prevents the uh release of the egg that is it prevents ovulation during your menstrual cycle or it makes your vagina fluid thicker to help prevent sperm from leaching the egg that does it inhibit fertilization lastly it causes changes in the uterus or it prevents the changes in the uterus to prevent the attachment of the fertilized egg the woman

Should become should be prescribed combined for a contraceptive 35 microgram of ethynae estradiol or even less its irrational use involved nearly the use of ethiopia eastern value by the nursing woman as a result this medication passes into the breast men and this may have undesirable effect not only on the woman but also on the nursing infant its irrational

Use also involves its use in pregnancy over dosage of ethynal easter diode causes bleeding in females and may also lead to nausea now the mechanism of action before understanding the mechanism of action let us understand the receptor to which the estrogen bind there are two main types of estrogen receptors estrogen receptor alpha and beta when the estrogen

Enter into the cell it binds to either of two these two receptors and it promotes the production of sex hormone binding protein this means that eth9 estrodiol does not travel in the body on its own instead it require sex hormone binding protein to be transported through the blood or plasma to the rest of the body where it is required its main mechanism as i’ve

Discussed previously that when it is used as a contraceptive it either suppresses the ovulation or it thickens the cervical mucus to prevent the travel of sperm or it prevent the changes in the endometrium that is required for the implantation of the fertilized egg as you know that ovulation is bring about by the neutralizing hormone so 89 easter diver decreases

The neutronizing hormone thereby decreasing ovulation or it decreases the vascularity of the endometrium which is required for the implantation of the fertilized egg it also increases the sex hormone binding globulin now the dose women should be prescribed combined oral contraceptive with 35 microgram of ethenite easter diode or even less combined old contraceptive

Containing 50 micrograms of ethynyl easter dial should not be used for contraceptive contraception instead it is used for the acute treatment of uterine bleeding when ethenite estrodiol is used in hormone and replacement therapy its dose is 0.65625 mg per day not in a regular manner but in a cyclic manner that is we start from day one till day 25 and on the day 10

To day 14 progesterone in the form of metroxy progesterone is given in a dose of 2.5 micro mg daily uh when it is used in postmenopausal symptoms its dose is 10 to 15 microgram only once a day in case of prostate cancer its dose is 0.15 to 1.5 mg orally once a day in case of primary ovarian failure its dose is 10 to 15 microgram orally once a day and in case

Of menstrual disorder its dose is 20 to 50 microgram orally once a day starting from day 5 to day 25 of each cycle now the drug interaction from this chart i will discuss the most common one that is a carbos the therapeutic efficacy of a carbons can be decreased when it is given with the ethanol estradiol similarly in case of acetaminophen the serum concentration

Of acetaminophen is decreased when it is given a longer in combination with with ethenite estradiol similarly in case of epsismav 89 destroyed iron can decrease the anticoagulant activity of fccla therefore uh ethinite estradiol should not be given in these drugs because it decreases either the concentration or either decreases its potency common brand name is

Osteodose which is the product of galaxy pharma limited the drug molecule is destroyed ion dose 60 mg it is available in the form of gel you can see the picture toxicity when eating estrodiol is given in high doses it can lead to withdrawal bleeding nausea vomiting breast tenderness abdominal pain drowsiness or even fitting while managing the toxicity of ethynone

Easter dial we also need to monitor the potassium and sodium concentration and also the signs of metabolic acidosis now the alternatives easter diol 17 beta is the natural estrogen which can be given in place of ethiopia strong and can be used in combined oral contraceptive now the precautions there are a lot and a lot of precautions that you need to follow uh

If you you need to tell your doctor if you have a medical history of any of these like migraine headache blood clots stroke eye diseases high blood pressure diabetes obesity asthma high cholesterol levels seizures even heart problems kidney liver problems cancer you need to tell your patient you need to tell your doctor about all this if you have a history of any

Of these uh this drug can cause as i’ve discussed in the previous slide that this drug causes hyperpigmentation this gardening of skin is usually observed on the face remember that sunlight may intensify this darkness and you need to avoid the prolonged sun exposure and sun lamps also you need to consult your doctor regarding the use of sunscreen and protective

Clothing now the phase normal precautions uh the precautions also include that if you become pregnant or you think you may be pregnant you need to inform your doctor immediately secondly avoid pregnancy for at least one month after stopping this medication by this time you can use non-hormonal birth control also you need to tell your doctor immediately if you’ve

Missed your menstrual beard since this medication must not be used if you’re pregnant this medication passes into the breast milk and we have undesirable effect on the nursing infant so you need to consult your doctor before breastfeeding now the contraindication this medication must not be used during pregnancy it is contraindicated in patients of breast cancer

Uh also estrogen or ethnic steroid oil is contraindicated in patients with genital feeding and thromboembolic disorders now the case is study a 30 years old woman with no history of breast cancer stroke and angioedema visits her gynecologist for birth control advice her blood pressure was found to be 120 by 82 millimeter meter edgy and her weight was 56 kgs what

Advice would you think my gynecologist would would give her this is where biochemistry reserved all these levels you can see are in uh in the normal ranges so let’s proceed towards the case study subjective eight she is a 30 year old woman she is a woman she has been visiting her gynecologist for birth control advice she has no family history of breast cancer

Stroke or angioedema currently she is taking momentation now the objectives the vital signs include blood pressure 120 by 82 mmg which is normal lab report sodium level is 143 millimole per liter and it is not lying in the normal range potassium level is 3.2 millimole per liter it is also in the normal range you can see from the normal range urea level is 7.2

Millimole per liter it is also in the normal range hemoglobin level is 10.4 it is slightly below the range so you can say that she’s slightly animate white blood cell count is also normal now the assessment as she is a completely healthy woman so the birth control films can be prescribed to her organic policies would give her oral contraceptive as this product

As she only she herself wants something oral contraceptive a gynecologist would give her a medication that consists of two these two hormones the amino gastrin which is before which is the progesterone and ethynae estradiol which is the form of estrogen she need to take one tablet once in a day how to start taking this tablet there is a starter schedule those

Should begin on the first sunday after the onset of menstruation if the menstrual periods start on the sunday then she need to take the first tablet that very day secondly uh the dough starts on the first day of the menstrual cycle taking one tablet once per day okay this is very important information she in case if she mis missed any dose she need to take the

Dose as soon as possible she need to continue the remaining doses at usual time even that mean two roses once a day this is the instruction that gynecologists need to give to her patient to achieve maximum contraceptive effectiveness the oral contraceptive pill must not be taken must be taken exactly as directed at the interval not exceeding 24 hours women

Should be instructed to use an additional method of protection until after the first seven days of administration in the initial cycle if squatting or breakthrough bleeding could occur the patient should continue the medication according to the schedule if spotting and breakthrough bleeding purses then the patient should notify her physician if the patient misses

One pill she should be instructed to take it as soon as she remembers and then take the next pill at the regular time the patient should be advised that missing a pill can cause spotting or light bleeding and that she may be a little sick to her stomach on the day she takes the miss pill with her regular schedule pit if the patient has knits more than one thing

This means that taking more than one fail at a time can cause stomach disturbance so she should take one till once a day these are the reference from where i’ve taken all this content thank you

Transcribed from video
Ethinyl Estradiol By Pharmacy by Dr. Shahana wahid

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