Hello this is isamavrazil and today we are going to be learning about meat we are estomeprazole we have a genetic name of s omeprazole magnesium having brand names of nexum and nexum24 are lexing24r is indicated to adults having frequent heartburn while nexium is syndicated to many acid related conditions we have a chemical name of magnesium 5 methoxy 2
Format oxy 3 5 diameter pyridine 2 methyl sulfanel melzamidazole 1i trihydrate my partner is up next to discuss our drug classification for density category and mechanism of action now let’s proceed to our drug classifications our therapeutic drug classification is anti-ulcer agent it lowers acid production in the stomach which prevents ulcer it also prevents
Gastric damage from the use of non-steroidal anti-inflammatory drugs our pharmacologic drug classification is protein pump inhibitor it suppress gastric acid secretion by specifically inhibiting the hydrogen potassium adenosine triphosphate enzyme system on the secretory surface of the gastric parietal cells let’s talk about our pregnancy category are we
Safe to be taken by pregnant women the answer is yes we belong to pregnancy category b which means that animals or production studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women next up our mechanism of action work by blocking the enzyme the wall of the stomach that produces acid by
Blocking the enzyme the production of acid is decreased and this allows the stomach and esophagus to heal thank you partner for discussing those now i’m back to tackle about our pharmacokinetics we are administered thoroughly as entirely coated granules and rapidly absorbed with big plasma levels occurring approximately one to two hours after those our absolute
Value availability is 64 after a single dose of 40 milligrams and increases to 89 after repeated once daily administration it is also important to remember that food intake both delays and decreases our absorption for our distribution we are 97 plasma protein bond then we are extensively metabolized in the liver by the enzyme cytochrome p450 and now for our
Excretion we are eliminated nirin by 80 and 20 in the pieces our plasma elimination half-life is approximately one to one and a half hours get to know us more by knowing when you should use us and when you shouldn’t here is our indications and contraindications first let’s start with our indications we are indicated to be used for frequent heartburn hepatic
Impairment gastro is the failure reflux disease with erosive esophagitis ulcers and persistent cough let’s go to our contra indications the following conditions are contraindicated with this drug inadequate of vitamin b12 osteoporosis systemic lupus erythematosus diarrhea from an infection with clostridium diffusal bacteria severe liver disease allergies to
Protein pump inhibitors and patients 18 years old and below now let’s head on to our side and inverse effects the essential nervous system we may cause nervousness to the cardiovascular system we may cause abnormal heartbeat while in the muscular system weakness leg terms and muscle pain can be expected also with long-term use we may increase the risk of
Cholesterol and fecal infection and osteoporosis related fractures of the hip wrist or spine therefore it is important to use the lowest losses and shortest duration of treatment necessary for the condition being treated the nursing responsibilities before administering isomeprazole the nurse must first assess epigastric or abdominal pain question history of
Hepatic impairment and pathologic bone fractures evaluate for therapeutic response question if gi discomfort nausea and diarrhea or monitor for a cold blood observe or hemorrhage in patients with peptic ulcers inspect the skin for lesions rash paritis and dryness to identify possible adverse effects assess respiratory rate and rhythm note evidence of cough
Hoarseness and epistaxis to monitor for potential adverse effects of the drug assess for neurological status including level of orientation effect and reflexes to evaluate for cns effects of the drug during administration the nurse must administer the drug appropriately before meals to ensure that the patient does not open chew or crush capsules they should
Be swallowed a hole to ensure therapeutic efficacy of the drug ensure safety and comfort institute a bowel program monitor nutritional status ensure follow-up provide patient support and educate the patient after the administration of islamophobe the nurse must monitor patient response to the drug including relief of gi symptoms caused by hyperacidity and
Healing of erosive gi lesions monitor for adverse effects including gi effects cns changes dermatological effects and respiratory effects monitor the effectiveness of comfort and safety measures and compliance with the regimen lastly evaluate the effectiveness of the teaching plan and that’s it for isometric zoom bye-bye hi i’m ansel brazil and today you are
Going to know more about me hi there glanzo prezzo is our name and it is our generic name we have brand names of privacy privacy solution and privacy 24hr this is our chemical name welcome to my drug classification just like asymposal my therapeutic drug classification is anti-ulster agent and my pharmacologic drug classification is proton pump inhibitor moving
On let’s now talk about my pregnancy category they said that they cannot cause fetal harm but i have limited research in human pregnancies any guess as to what my pregnancy category is right it’s pregnancy category b now i’m gonna tell you my mechanism of action as a product pump inhibitor i am a pro drag and requires protonation via an acidic environment to
Become activated once protonated i am able to react with cysteine residues on parietal hydrogen potassium atpase resulting in stable disulfides as ppis in general we are able to provide prolonged inhibition of acid secretion due to our ability to bind covalently to our target yes partner thank you so much now let’s head on to our pharmacokinetics we are
Rapidly absorbed from the gastrointestinal tract but food delays absorption and reduces our bioavailability of approximately 50 to 70 percent and our time to pick plasma concentration is about one and a half to two hours our plasma protein binding is approximately 97 our volume of distribution is about 15.7 liters as for our metabolism we are extensively
Metabolized in the liver via hydroxylation primarily by cyp to c19 isoenzyme which inactivates fiber hydroxyl encephalone and a lesser extent of cyp3a4 isoenzyme thus in turn inactivates lysophyseal cell phone lastly we are mainly excreted via faces by 67 and 33 percent in the urine 14 to 25 percent remain as metabolites in our elimination half-life is about
One to two hours we are now going to talk about my indications and contraindications starting with my indication i am medicated for the short treatment of active duodenal ulcer short-term treatment of erosive esophagitis long-term treatment of pathologic hyper-secretory conditions including zollinger ellison syndrome maintenance of healed the oddnal ulcer or
Erosive esophagitis short-term treatment of gastric ulcer short-term treatment of symptomatic gastroesophageal reflux disease helicobacter pylori eradication to reduce risk of duodenal ulcer reoccurrence treatment of non-steroidal anti-inflammatory drug-related ulcer in patients who continue to take non-steroidal anti-inflammatory drugs reduction in risk of
Non-steroidal anti-inflammatory drug-related ulcers in patients who have history of gastric ulcer but who needs non-steroidal anti-inflammatory drugs for my contraindications i am contraindicated for the following conditions check with your precision if you have any of the following diarrhea from an infection with clostridium different bacteria inadequate
Vitamin b12 low amount of magnesium in the blood severe liver disease interstitial nephritis osteoporosis a condition of weak bones broken bone and hypersensitivity to proton pump inhibitors let’s proceed to my side and adverse effects my side and adverse effects on the digestive system includes diarrhea nausea abdominal pain constipation and vomiting for the
Cardiovascular system i have chest pain and irregular heart rate in the muscular system we have muscle pain in the nervous system we have headache insomnia vertigo and dizziness in the respiratory system we have upper respiratory infection and cough nursing responsibilities before administering as to the patient the nurse must perform history taking and
Physical examination that include assessment of possible contraindications and questions involving history of allergy the proton pump inhibitor which is s to reduce the risk of hypersensitivity reaction and current status of pregnancy relaxation because of the potential adverse effects on the fetus or the nursing baby also the nurse must monitor cbc hepatic
Or renal function test and assess for therapeutic response lastly the nurse must obtain c difficult pcr test in consideration with persistent diarrhea fever and abdominal pain then the responsibilities of the nurse during is monitoring the patient response to the drug for example relief of gi symptoms caused by hyperacidity and healing of erosive gi lesions
Next is monitoring for adverse effects and the effectiveness of comfort and safety measures as for their nursing responsibilities after the nurse must conduct patient or family teaching then evaluate the effectiveness of the teaching plan for which the patient can name the drug and dosage and describe adverse effects to watch for that’s all for the nursing
Responsibilities that is all from isometrizal and then soprazo thank you bye bye-bye
Transcribed from video
Esomeprazole and Lansoprazole by Nelmida and Bartolini By Batch Kunzite
