Epinephrine Signalling Pathway,
In this video we’ll be discussing about the epinephrine signaling pathway which regulates glucose metabolism the signaling molecule in this pathway is the epinephrine hormone and the receptor for this is beta adrenergic receptor which is a type of gpcr protein and this gpcr in turn regulates the stimulatory g protein known as gs and the second messenger for the
Transduction of signal involves the cyclic amp which mediates the signal further here in this diagram we have the cell which is having beta adrenergic receptor in its membrane which belongs to gpcr family of proteins and to it and ineq to trimeric g proteins are bound as g alpha g beta and g gamma and here in this diagram we have the g alpha protein having gdp
Bound then looking at the right we had adenylyl cyclase in the membrane which is the class 3 adrenal cyclase now let’s initiate the signaling pathway we know the signaling molecule for this pathway is the epinephrine it comes in and binds with the beta adrenergic receptor as shown in the diagram and then upon binding we have the transformational change in the gpcr
Domain with which the gdp bound with the g alpha protein is replaced by gtp as shown in the animation and this process is mediated by gef that’s garnocy nucleotide exchange factor so the binding of gtp with g alpha subunit drives the activation of g protein and this subunit that is g alpha disassociates from rest of the g protein then from here it leaves and binds
With the adenylyl cyclase as shown in the animation upon binding with adenylyl cyclase the adrenal cyclase is activated which mediates the conversion of atp to cyclic amp and these camp molecules then attaches with the inactive form of protein kinase a to its regulatory subunits and renders the catalytic subunits of pka active now this active pk or ac2 protein
Kinase a in the form of catalytic subunits drives the activation of different enzymes like first of all we have inactive phosphorylase kinase we see here the active form of pka acts upon it and we get active phosphorylase kinase and then this phosphorus kinase acts upon the inactive glycogen phosphorylase enzyme and makes it active and finally in the end this
Glycogen phosphorylase acts upon glycogen and mediates the breakdown of glycogen into glucose one phosphate which is used in metabolism later on in different pathways so this is how epinephrine mediates the signaling in order to regulate the glucose metabolism i hope you liked the video if you liked it give it a thumbs up and supporting my work on patreon or
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Transcribed from video
Epinephrine Signaling Pathway By Hussain BiologyliveBroadcastDetails{isLiveNowfalsestartTimestamp2021-08-04T133012+0000endTimestamp2021-08-04T133511+0000}
