Hi if you’re familiar with adrenaline rush then you will be familiar with flight-or-fight response so which tells us in a confused situation whether to fight back or run away but i’m not going to talk about flight and fight response rather i would talk about how epinephrine regulates one aspect of this flight and flight response and under stress condition how
Epinephrine regulates glucose sentences and glucose is important because glucose is the raw source of fuel for the body under stress condition definitely let’s say a scary dog is barking at you are trying to bite you so your immediate response would be running away from that dog in order to run away your muscles of the neck need to contract and expand enough very
Fast rate in other words it needs a lot of energy atp but what does that atp come from definitely muscle cells need a lot of glucose fuel to make atp now in the muscle cell where does glucose come from in a muscle cell which is kind of a resolver of reserve glucose in format of glycogen need to be broken down immediately to glucose and that glucose could be in
Turn used as a fuel to permit and make atp and thereby contracting muscle very fast and running away so let’s just see how the adrenaline rush works so epinephrine by not to the beta adrenergic receptor on the muscle cells and allowing g-protein cascade to occur the g alpha subunit of this g protein replaces its gdp with gtp and gets activated it in turns activate
Adenylate cyclase which formed atp to cyclic a&p a cyclic emp activates protein kinase a or pka and releases its catalytic subunit from the regulatory subunits the catalytic subunits are important the catalytic subunit of pka phosphorylates phosphorylase kinase and converts it into an active form of phosphorus now first of all i understand it is very important
Because it controls several important rate-limiting enzyme in the glycogenolysis pathway where glycogen is broken down to glucose so let us see what phosphorylase kinase control phosphorylase kinase convert phosphorylase to an active format now once phosphor is is activated it can start the process of glycogenolysis where glycogen would be broken down to produce
Glucose so we saw that how epinephrine can in turn work by a g-protein signaling cascade lead to protein kinase a activation and thereby activation of phosphorus which is a key enzyme in glycogen eliza’s pathway and thereby a fast glucose burning mechanism could occur in the muscles and that gives us the energy to run away from that scary talk so if you like my
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Transcribed from video
Epinephrine and regulation of glycogenolysis By Animated biology With arpan
