Drugs Inhibiting Brain Cholinergic Transmission – Parkinsons Disease ( Part 8 ) – CNS Pharmacology

►𝐉𝐨𝐢𝐧 𝐓𝐡𝐢𝐬 𝐂𝐡𝐚𝐧𝐧𝐞𝐥 𝐓𝐨 𝐆𝐞𝐭 𝐀𝐜𝐜𝐞𝐬𝐬 𝐓𝐨 𝐏𝐞𝐫𝐤𝐬 :-

So let me discuss the last group of drugs which are used in the treatment of parkinsonism so if you go back to the pathophysiology of the parkinsonism so i have discussed that parkinsonism is occurring mainly due to imbalance between the dopamine and as well as acetylcholine the dopamine levels they are reduced and acetylcholine levels they are increased so we

Have seen a group of drugs which were increasing the dopamine levels now let me discuss the group of drugs which will decrease that acetylcholine in patients with the parkinsonism so those are the drugs which will inhibit the brain cholinergic transmission so cholinergic neurotransmitter is the acetylcholine so when you are inhibiting the brain cholinergic

Transmission indirectly or reducing the acetylcholine so for this we have central anticholinergic drugs the central anticholinergic drugs like trihex afeni delhi which is nothing but the benz ox all and then we have pro cycled in then we have been strapped in then we have orphan adran and then we have be paired in these are the drugs which are useful for

Drug-induced parkinsonism alright so these drugs remember they are useful for drug-induced parkinsonism now what are those drugs which will cost the drug-induced parkinsonism right so we have certain antipsychotics right certain antipsychotics and as well as metoclopramide which is which is an anti empty graph both of these drugs what they do is they block

The d2 receptors right they block the dopamine receptors so once this particular dopamine receptors are blocked even though dopamine is there the dopamine cannot act so remember in this condition of drug-induced parkinsonism increasing the dopamine levels is not effective right increasing the dopamine levels is not effective because the receptors on which the

Dopamine has to act are already occupied by the antipsychotics or metoclopramide so therefore we have to use an alternative therapy that is anticholinergics our preferred right we have to use an alternative therapy that is anticholinergics our preferred so in drug-induced parkinsonism what we give is we give anticholinergics right so that was the examples the

Beeper teen benched open right and ben’s acts all those are the drugs what we give in these patients with the drug-induced parkinsonism not only this particular anticholinergic drugs you take the first-generation antihistamine –ax remember the first-generation antihistamine ik’s they have antimuscarinic property right they have antimuscarinic activity now

What are those first-generation antihistamine aches like you take promethazine right you take this promethazine and the other drug that is diphenhydramine right the other drug that is diphenhydramine these can these are having antimuscarinic activity even these drugs also can be used for this particular the drug-induced parkinsonism now because they’re having an

Anticholinergic effect and they’re having antimuscarinic effect so if you take the adverse effects of these drugs remember the adverse effects of these drugs they include a urinary retention right this will cause blurring of vision right this will cause blurring of vision so remember these are all your anti-masonic side effects and even the salivary secretion

Is reduced so they’ll have dry mouth and even the gi motility is reduced the individual will have constipation when this individual will have constipation so these are the adverse effects of these drugs urinary retention blurring or fusion dry mouth and as well as constipation so these are the drugs acting by inhibiting the brain cholinergic transmission so that

Is in case of drug-induced parkinsonism we use this particular group of drugs and the drugs which will cause parkinsonism is antipsychotics and as well as metoclopramide which will block the d2 receptors and the drugs what we use is anticholinergic drugs and first-generation antihistamine eggs which are having anti-masonic property and the drugs are promethazine

And as well as diphenhydramine because they are having the anticholinergic property or anti-masonic property the adverse effects include the urinary retention blurred vision dry mouth and less constipation

Transcribed from video
Drugs Inhibiting Brain Cholinergic Transmission – Parkinson's Disease ( Part 8 ) – CNS Pharmacology By Dr.G Bhanu Prakash Animated Medical Videos