Drugs for Heart Failure (Made easy) Part-2 | Blood Pressure | ACE inhibitor | Heart Rate |
Hello guys i am surely welcoming you to the show pharmacy and medical crash course division in the knowledge club online at previous episode we learned about reasons of heart failure and classification of drugs for heart failure today we will learn about the drugs for heart attacks and failure the renin angiotensin blockers heart failure leads to activation of
The renin angiotensin system via two mechanisms number one increased renin’s release by just a grammar cells in renal afferent arterial occurs in response to the diminished renal perfusion pressure produced by the failing heart and number two the remaining release by the juxtaglomerular cells is promoted by sympathetic stimulation the production of antutus in two
A protein vasoconstrictor and the subsequent stimulation of aldosterone release that causes salt and water retention leads to the increases in both preload and afterload that are characteristics of the failing heart in addition high levels of characteristic of the failing heart ambulance in two and of aldosterone have direct detrimental effects on the cardiac
Muscle flavoring remodeling fibrosis and inflammatory changes know more about this stay tuned up to end because if you skip the lecture you can miss our valuable points in between lecture so stay tuned up to end i am going to start today’s episode let’s start number one type of drug is the angiotensin converting enzyme inhibitor angiotensin converting enzyme
Means ace inhibitors are the agents of choice in hf these drugs block the enzyme that cleaves angiotensin 1 to form the potent vasoconstrictor angiotensin ii these agents also diminish the rate of bradycardine inactivation memorize it the vasodilation occurs as a result of the combined effects of lower vessel concentration caused by diminished level of angiotensin
2 and the potent vasodilating effect of decreased fragility okay by reducing circulating angiotensin two levels sa individuals also decrease the secretion of aldosterone resulting in decreased sodium and water retention the mechanism of action the actions on the heart that is the ac inhibitor decrease vascular resistance when a stone and blood pressure resulting
In an increased cardiac output acv individuals also blunt the usual angiotensin to mediated increase in epinephrine and aldosterone seen in heart failure fca inhibitor improve clinical cells and symptoms in patients also receiving thiazide or loop diabetics and or digoxin the use of ac individuals in the treatment of hf has significantly decreased both morbidity
And mortality for example we can see as the ac inhibitor in our fleet decreases the cumulative mortality in patients with congestive heart failure the reason behind it the reduction in moderating is due to primarily to a decrease in deaths caused by progressive heart failure treatment the energy also reduces acne death myocardial infarction and strokes similar
Data have been obtained with other se ingredients also indications ac individuals may be considered for single agent therapy in patients who present with mild disney on exertion and do not show signs or symptoms of volume overload ac individuals are useful in decreasing heart failure in asymptomatic patients with an ejection fraction of less than 35 percent that
Is at the left ventricular dysfunction patients who have had a recent myocardial infarction also benefit from long term ac in video therapy patients with the lowest ejection fraction show the greatest benefit early use of sa inhibitors is indicated in patients with all stages of left ventricular failure with and without symptoms and therapy should be initiated
Immediately after myocardial infarction pharmacokinetics all the ac inhibitors are adequately but incompletely absorbed following oral administration the presence of food may decrease absorption so they should be taken on an empty stomach except for catapult ac inhibitors are products that actually require activation by hydrolysis via hepatic enzymes radar
Elimination of the active moiety is important for most ac inhibitors and here also an exception have been persinophil plasma half-lifes of active compounds vary from 2 to 12 hours although the elevation of sc may be much longer the newer compounds such as ramifical and fascinating require only once a day dosing adverse effects these include postural hypotension
Renal insufficiency hypercalamia angioedema and a persistent dry cough the potential for symptomatic hypotension with se inhibitor therapy requires careful monitoring aca individuals should not be used in pregnant women because they are phetotoxic some common inhibitor drugs are capital inner approval personnel pill listener grill coin approved benzene venezuela
Moist extreme perindoprine ramiful triangular plane p denotes the product active metabolites produced by the esterification of the mental second type of drugs are angiotensin receptor blockers angiotensin receptor blockers arvs are non-peptide orally active compounds that are extremely important competitive antagonist of the angiotensin type 1 receptor lossartin
Is a prototype drug aivs have the advantage of more complete blockage of ambitions in action because acn individuals inhibit only one enzyme responsible for the production of angiotensin ii further the airbs do not affect bradycardine level although aries have actions similar to those of sea images they are not therapeutically identical even so airbnbs are a
Substitute for ac invaders in those patients who cannot tolerate the latter general mechanism of actions on the cardiovascular system all the airbs are approved for treatment of hypertension based on their clinical efficiency in lowering blood pressure and reducing the morbidity and mortality associated with hypertension as integrity that they are used in heart
Failure is as a substitute for sea inhibitors in those patients with severe cough or angioagina pharmacokinetics all the drugs are already active and require only once a day dosing lasagna the first approved member of the class differs from the others in that it undergoes extensive first pulse hepatic mineralism including conversion to its active metabolite the
Other drugs have inactive metabolites elimination of metabolizer and parent compounds occurs in the urine and phases the proportion is dependent on the individual drug all are highly plasma protein-bound that is greater than 90 percent and excision happens for candy saturn have large volumes of distribution adverse effects arvs have an adverse effect profile
Similar to that of scenarios however airbs do not produce cough in pregnancy some common types of drugs used as a aerobies that is the lossergen versatile so with today’s lecture after this next episode we will discuss on drugs the rest of the part of heart failure revise the all episodes on heart thoroughly i made it step by step accordingly here to all
Previous episodes list on heart anatomy and physiology chapter and cardiac pharmacology chapter you will get all links at the discussion part of this video or you can visit our channel before heading to this episode if you like this video please like share and comments free don’t forget to subscribe our channel if you already subscribed then thanks a lot and
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Drugs for Heart Failure (Made easy) Part-2 | Blood Pressure | ACE inhibitor | Heart Rate | By Knowledge Club Online
