Diuretics are the drugs which increase the urine volume or increases excretion of water and sodium in urine.
Knifes are the drugs which increase the urine volume or increases excretion of water and sodium in urine the clinical use of diuretics includes relieving edema and fluid retention caused due to congestive heart failure renal diseases and hepatic cirrhosis diuretics are also used in the treatment of hypertension the diuretics act at different sites of nephron osmotic
Diuretic sin clewd glycerol and mannitol after intravenous administration it is filtered at the glomerulus but is not reabsorbed from the renal tubules in osmotically attracts and retains water as it moves through the nephron and into the urine this action reduces the tubular sodium concentration in the concentration gradient between the tubular fluid in cells and
Thereby retards the reabsorption of sodium osmotic diuretics are used for inducing diuresis for reduction of intraocular pressure in glaucoma mannitol is specifically used to reduces in trace reveler pressure in cerebral edema the proximal tubules nephron is site of action of carbonic anhydrase inhibitors such as acid as olamide indoors olamide carbonic anhydrase
Catalyzes the reversible conversion of hydrogen ion and bicarbonate to carbon dioxide in water thereby enabling the reabsorption of sodium bicarbonate this process is inhibited by carbonic anhydrase inhibitors leads to corresponding increase in its renal excretion sodium bicarbonate in water carbonic anhydrase inhibitors are used in glaucoma epilepsy high altitude
Sickness and they are also used to alkalinize urine in urinary tract infection and to promote excretion of certain acidic drugs the thick ascending limb of the loop of henna liz the site of action of high ceiling or loop diuretics like at the clinic acid furosemide you mennonite inter as amide this segment has a high capacity for absorbing sodium and chloride the
Loop diuretics inhibit the sodium potassium and chloride symporter this action produces diuresis that is much greater than that of other diuretics this is the reason why they are called as high ceiling diuretics loop diuretics are used in in treatment edema irrespective of etiology of edema cardiac hepatic arena the high ceiling diuretics are preferred in congestive
Heart failure for rapid mobilization of edema fluid high ceiling diuretics are used in hypertensive emergencies when renal insufficiency is also present the distal tubules site of action of thiazide such as hydrochlorothiazide vents thiazide and thiazide like diuretics such as cloth a low tone mottola zone sheath amide in death amide these diuretics act mainly on
The early segments of the distal tubules where they inhibit sodium and chloride reabsorption by binding to the symporter responsible for the electro neutral code transport of sodium and chloride excretion of sodium chloride and accompanying water is increased thiazide and like diuretics are preferred treatment of hypertension in mild edema the collecting duct is
Site of action is potassium sparing diuretics in collecting duct reabsorption of sodium is coupled with potassium and hydrogen excretion the spironolactone reduced sodium reabsorption by antagonizing aldosterone inhibits aldosterone induced proteins aips which promotes sodium reabsorption the other potassium sparing diuretics amiloride and try entering cause of
Blocking of sodium channels the potassium sparing diuretics are used in conjunction with other diuretic to prevent diuretic induce hypokalemia or excessive potassium excretion share and subscribe the channel for more video regarding pharmacology
Transcribed from video
Diuretics clinical uses and mechanism of action#acetazolamide #furosemide #spironolactone #thiazide By Just Pharmacology
