Dexamethasone for COVID-19 | Mechanism of action | cytokine storm | side effects
Learning with artworks like drawing and calligraphy. mechanism of action which is recently approved sar-cov 2 is a novel coronavirus reported dexamethasone recently approved to be used dexamethasone is a member of corticosteroids also known as glucocorticosteroids, glucocorticoids dexamethasone is a very potent, long acting being a steroid it has a lot of diverse actions,
Action, leading to cytokine storm diminishing cytokine storm is responsible for many deaths in older peoples. patients are not strong enough as the young proinflammatory cytokines and anti-inflammatory cytokines are produced in aged patients which result in cytokine storm. as it acts as immune suppressive agent and mean selecting of dexamethasone for treating dexamethasone
Is only palliative; and do not disease continues to progress while clear manifestations are reduced. while to show effect at transcriptional level readily across the membrane of the target by binding to intracellular receptors named cells especially t cells to reduce sars-cov 2 infection. once dexamethasone have bound to gr, changes of these proteins, thereby exposing
Nuclear localisation signals on gr. where two gr molecules bind together as a in the promoter region of corticosteroid-responsive interaction of gr with gre classically leads the production of mrna which may encode anti-inflammatory stages for example annexin-1 or lipocortin-1 which promotes neutrophil detachment and apoptosis, b (nf-kb) i?b. less commonly, gr homodimers
Element to suppress genes, particularly those in controlling inflammatory process, the major synthesis of multiple inflammatory proteins these transcription factors are nuclear factor these are important transcription factors when the cell detects inflammatory stimuli as they are proinflammatory transcription and start transcription of the genes into such as cytokines,
Inflammatory enzymes, adhesion in these cytokines and specifically proinflammatory proinflammatory cytokines include ifn-?, ifn-?, il-1?, il-6, il-12, il-17, il-18, tnf-?, granulocyte-csf among them, interleukin-6 (il-6) is more important these cytokines will act on other cells to which eventually result in cytokine storm these proinflammatory transcription factors and play
A critical role in amplifying and spreading the inflammatory process. dexamethasone activated gr interact functionally and ap-1, without the necessity of binding these transcriptional factors are inhibited mechanisms and block their transcriptional in addition to this pathway, dexamethasone genes by regulating the expression of tristetraprolin for short ttp. and targeting
Them for degradation, it allows of inflammatory proteins after the inflammatory gene has been activated. be controlled and saved the life of many severe patients. these effects include, glaucoma, increased increased appetite, emotional retardation, hyperglycaemia, and hypertension. and indiscriminate use of corticoids is hazardous.
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Dexamethasone for COVID-19 | Mechanism of action | cytokine storm | side effects By MK MediGuide Lectures
