All about COLCHICINE medicine: colchicine dosage (1mg, 0.5 mg), colchicine uses, colchicine side effects, colchicine contraindications, colchicine interactions, colchicine mechanism of action (moa).
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The commercial names of colchicine are colchicine zite colchicum cycle t colesson colchris mitigare glopurba mechanism of action of colchicine it reduces the inflammatory response consecutive to the deposition of urine crystals in the joints since it decreases the leukocyte flow inhibits the phagocytosis of the urine microcrystals thus reducing the production of
Lactic acid avoiding an acid ph and with it the precipitation of the urete crystals therapeutic indications and pathology of colchicine oral route adults acute gout attack one milligram at the first sign of gout attack if pain relief is not achieved administer one milligram one or two hours after the first intake maximum two milligrams per day maximum dosage
Pattern four days in a row without exceeding a total accumulated dose of six milligrams during the four days preventive treatment of gout attacks during initial therapy with allopurinol or uricocerics milligram per day periodic illness or familial mediterranean fever from one to one milligram per day in two daily doses or in one single dose treatment of chronic
Gout one milligram per day children and adolescents under 18 years acute gout attack prevention of gout attacks and chronic gout there are not enough data to establish recommendations in this age group periodic illness or familial mediterranean fever children over 12 years old one milligram to two milligrams per day it can be divided into two daily doses or a
Single dose children four to six years old 0.3 milligrams to 1.8 milligrams daily children 6 to 12 years old 0.9 milligrams to 1.8 milligrams a day these doses can be given in a single or two doses moderate renal failure reduced dose by half or increased dose intervals contraindications of colchicine colchicine hypersensitivity pregnancy severe renal insufficiency
And patients undergoing hemodialysis severe hepatic insufficiency severe gastrointestinal disorders stomach ulcer heart disorders hematological alterations blood disgraces during the 14 days following the use of type 3 a4 or p glycoprotein inhibitors side effects and adverse reactions of colchicine diarrhea nausea vomiting abdominal pain another adverse reaction
Identified after the evaluation of pharmacovigilance data was liver toxicity warnings and precautions with colchicine renal failure or liver failure adjust dosage elderly cumulative dose in four days should not exceed three milligrams children debilitated or alcohol abusing patients risk of cumulative toxicity delete or reduce dose if diarrhea appears risk of
Leukopenia granulocytopenia thrombocytopenia pancytopenia aplastic anemia and myelosuppression perform periodic blood tests neuromuscular toxicity and rhabdomyolysis increased in elderly and kidney patients avoid grapefruit juice narrow therapeutic margin and in case of very toxic overdose do not exceed the dose as it can be fatal with hepatobiliary and renal
Insufficiency it may be necessary to adjust the dosage during treatment of acute gout attack the patient should be continuously monitored in case of renal or hepatobiliary insufficiency concomitant with the torva statin simvastatin previous tatin fluvastatin gemfibrazil phenofibrate phenol fibric acid or besofibrate themselves associated with myotoxicity digoxin
Or cyclosporine with colchicine may potentiate the appearance of myopathies liver failure and colchicine contraindicated in severe liver failure caution in hepatic insufficiency close monitoring and reducing doses kidney failure and colchicine contraindicated in severe renal failure caution in moderate renal failure reduced dose by half or increased dose intervals
Colchicine interactions caution should be exercised when colchicine is associated with active ingredients that are metabolized or interact with the cytochrome p450 system in particular with the type 3a4 isoenzyme or with the p glycoprotein powerful appearance of myopathies with concomitant use of atorvastatin simvastatin previous prevastatin fluvastatin gemfibrazil
Phenofibrate phenol fibric acid or bezafibrate digoxin or cyclosporine increased toxicity with chlorethromycin erythromycin or telethromycin type 3a4 substrates and inhibitors utriconazole ketoconazole indinovir nelfinavir ritonavir sequinovir grapefruit juice serum concentrations increased with azithromycin decreases the absorption of vitamin b12 pregnancy and
Colchicine no malformations or fetal or neonatal toxicity were observed after exposure to colchicine in a limited number of pregnant women with familial mediterranean fever however animal studies with colchicine have shown teratogenic effects therefore and as a precautionary measure due to the absence of controlled studies in humans and its passage through the
Placenta with the consequent risk to the fetus due to its mechanism of action its use during pregnancy is contraindicated breastfeeding and colchicine excreted in breast milk it is advisable not to administer it during lactation effects on the ability to drive with colchicine it has not been described to have any effect on the ability to drive vehicles or use machines
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Colchicine SIDE EFFECTS | Colchicine DOSAGE | Colchicine USES By Medicines/Diseases
