Clobetasol propionate is a highly potent topical corticosteroid indicated for dermatoses and plaque psoriasis.
Hi everyone today in this video let us discuss clobetasol propionate clobetasol is given as an ester form propionate so this globitol propionate is one of the topical corticosteroid among the corticosteroids this is one of the drug which is highly potent and it is available in the different dosage forms all these are used for topical purpose it is available as cream
Is also available as foam and even it is available as lotion all these formations are used to reduce the inflammatory response when they are locally applied on the skin because of high potency this drug should not be given by oral root as the systemic exposure increase the systemic side effects similarly clobetasol propionate should not be given by ophthalmic root
This again increase the systemic absorption as well as local effects on the eye and again this drug is not intended for the intravisional use then what is the use of this globetasol propionate the main purpose of this drug is for the treatment of skin inflammatory disorders for instance it can be used for the management of plague psoriasis where the inflammation
Associated with psoriatic flakes can be treated by this clobetasol propionate and for this purpose this drug is applied around two weeks and the treatment period can also be extended up to four weeks similarly this can be used for the treatment of eczema as well as pruritis so if this drug reduce the swelling itching and redness of the skin which are associated with
Inflammatory disorders today in this video let us see how this globetosol acts what are the important precautions side effects doses all these things we will discuss in this video first of all let us see the precautions of this tribe one of the important precaution of this drug is that clobit salt propionate is one of the highly potent corticosteroid sometimes it
Is also called as super highly potent because of this high potency even at small dose it can produce large seismic side effects and even this type can produce local skin reactions that’s why this drug should not be applied under arm even it should not be applied on the face as it may increase the risk of contact with the eye and systemic exposure and it’s also
Not applied on the groin area so these areas clobetazol propane it should not be applied similarly this drug is not indicated for the children as we have seen these studies available as a form as well as cream so these two formulations should not be applied in the children less than 12 years so those patients with a’s greater than 12 years clobit salt propionate
Can be used in the form of lotion this is applied in the patients with a is greater than 18 years because in the children probate cell propionate may suppress the hp axis resulting in the systemic side effects and it may reduce the growth of the children as well as it can produce mental retardation that’s why it is not given in the children less than 12 years
Similarly this stock can produce some skin atrophy it can reduce the thickness of the skin so in those patients already having the thinning of the skin the structure should not be applied because it can further increase the atrophy as well as it can increase the risk of seismic exposure and the important precaution is that clobetasol propionate can produce glaucoma
As well as cataracts so the risk of glaucoma cataracts or increase with many of the corticosteroids since crobatasol is a highly potent corticosteroid it can increase further risk that’s why care should be taken to avoid the contact with eye as it increase the glaucoma and cataracts within the patients similarly when this globetosol is applied on the skin few of
The molecules can be absorbed into the deeper layers into the skin where they can be transported to systemic circulation so once the systemic absorption is increased this drug can suppress hp axis hypothalamus pituitary adrenal axis by separation of hp axis the cortisol is somewhat less released which produce symptoms like cushing syndrome so in such patients we
Can observe increased blood glucose levels increased heart rate decreased bone strength decrease in the growth rate as well as mental retardation so all such effects can be observed with cystic exposure of clobetasol propionate particularly this is observed at a dose of greater than 50 grams per week that’s why the total dose of this drug should not be greater
Than 50 grams per week in order to avoid the suppression of hp axis similarly this drug should not be applied with the bandages or occlusive dressings which further increase the systemic exposure now what is the side effects of this trial the important side effects of this drug are mainly local side effects it can produce some dryness of the skin skin atrophy the
Thinning of the skin burning irritation stinging and it can also produce some winding of the blood vessels which can be clearly observed on the skin even it can produce contact dermatitis now let us see how this drug acts clobetasol propionate can act on the glucocard receptors present on the cytoplasm so once this drug binds to the glucocorticate receptors they
Can be internalized where it can be dimerized to produce gene transcription now this gene transcription produced the mrna which can be proceed to protein senses to produce various proteins such as lipo cotton one and nx in a1 so these mediators can produce anti-inflammatory cascade which reduce the inflammation similarly if you have the inflammatory mediators
Can act on their corresponding receptors which activates the nfkb pathway nuclear factor kappa3 this nuclear factor kappa b can interact with the dna where it produced gene transcription resulting in the release of various inflammatory mediators so this produce inflammation which is again controlled by clobetasol propionate now this globetrol propionate can
Interact with the dna where it can inhibit the activity of nfkb pathway so this reduced the release of inflammatory mediators by all of these actions clobetasol propionate can reduce inflammation it can also increase the attitude of nx in a1 which inhibits the activation of cox pathway now what is the chemical nature of this type so this is the structure of
Clobetasol propaneate we can clearly observe it is hang the prima one for diene nucleus with two ketone groups so we can write the suffix as pigna 140 in 320 dion here we can observe the two hydroxyl groups one hydroxyl group is free so we can write this as 11 beta 17 dihydroxy but at the 17th question it forms an ester with propionic acid so we can write the
Suffix as propionate and finally we can identify further side chains 21st portion chlorine group is present so 21 chloro ninth position floating rupees present so nine fluoro and 16th position methyl group is present so 16 beta methyl that is a complete name of clobetasol propaneate how it is given this drug is available as cream foam as well as lotion all these
Are available at a strength of 0.05 percent so clobetasol propionate should be applied two times a day and the total dose per week should be less than 50 grams in the treatment of psoriasis the treatment should be continued up to two weeks even after two weeks inflammation is not reduced then it can be further continued up to four weeks beyond the four weeks it is
Not recommended as it increase the risk of separation of hp axis so that’s about this drug clobetasol propaneate which is a topical glucocorticoid which is a highly potent corticosteroid which should be applied at low dose in order to reduce a systemic exposure but this track should not be applied on the face under arm groin areas and you do not contact with the
Eye to reduce the risk of glaucoma and cataracts even it is not recommended in the children in the children as greater than 12 years this drug should be used local side effects are the important precautions that should be maintained with this clobetasol propionate and you can produce some dryness of the skin burning sensation and it can also produce some atrophy
Of the skin which reduce the skin thickness all these side effects should be considered during the treatment of globetosol propionate so that’s about this track that’s for today hope you have enjoyed this video if you like this video please subscribe to our channel share this video with your friends post your comments in the comment box thank you for watching this video
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Clobetasol propionate cream By egpat
