Oh bodies and near the terminal end of the axon binding of nicotine leads to activation of these nicotinic acetylcholine receptors via a conformational change and allows for ion exchange as we peered out the inactive receptor we see that the channel is closed once the binding sites are occupied the channel is activated eight opens and i am exchange begins allowing the
Depolarization of the neuron resulting in an action potential the action potential travels from the vta to the terminal end of the axon located in the nucleus accumbens as the neuron is depolarized the neurotransmitter dopamine from the vesicle within the presynaptic bulb of the terminal axon as the synaptic cleft this is believed to initiate responsible because
Nicotine’s effect is short-lived and levels quickly decrease dopamine levels decline at a rapid rate as well this process is what eventually leads to the craving for more nicotine each time nicotine enters the system dopamine levels surge however with prolonged smoking a tolerance to nicotine will develop this tolerance is a result of nicotinic acetylcholine
Receptors being upregulated and becoming desensitized to nicotine focusing in on the ventral tegmental area we observe camping’s varenicline for pay the ticket in spokeo
Transcribed from video
Chantix CSC First Cut By Sabrina Leier
