🩹 Dermatology Course:
Good morning everyone and welcome back today we’re going to be talking about ace inhibitors so let’s very simply understand the mechanism for action we know that a mutants engine is secreted from the liver and it becomes a mutant sin 1 by runnin from the kidneys and then the enzyme is convert that to a mutants into the enzyme is constantly also breaks down breda
Canyon now both of these functions of the enzyme ace will actually increase blood pressure angiotensin ii will directly and indirectly increase blood pressure by aldosterone and other mechanisms and brady canyon normally decreases blood pressure by wizard dilatation but s breaks bread canyon and here is the fun part if we can block ace we will decrease angiotensin
Ii and decrease blood pressure and nothing will break brady canyon so it will accumulate an increase and brady canyon is a visitor later search will decrease blood pressure ace inhibitors are the medications ending with the softlocks prell the mechanism for action as we said they inhibit this enzyme which will decrease and retention to and increase brady cannon the
Main use of ace inhibitors is hypertension especially that in the presence of diabetes because ace inhibitors will also protect the kidneys and the most common complication diabetes is diabetic nephropathy so if someone has hypertension and diabetes it only makes sense to use as a neighborhood so they can treat both recent studies also shown that atherosclerosis
Has some link with a distance into so by using as an enabler we will decrease angiotensin 2 and decrease this atherosclerosis the most common side effect of ace inhibitors is dry cough as we know ace inhibitors will increase brady canyon and brady canyon internal increase prostaglandin which will cause dry cough so the cause of dry cough is actually by declining
Not the medication itself ace inhibitors will also cause angioedema which is also caused by brady canyon hereditary angioedema the disorder caused by c1 storage inhibitor deficiency so as neighbors are contraindicated with these patients as a members will increase q18 for 2 to 5 days which should go back to normal in two to three weeks one very common side effect
Is that causes first those hypertension the contraindications as we said c1 estrogen hemorrhoid deficiency which causes angela dima bilateral renal artery stenosis and pregnancy because it strategy neck and here’s a small quiz so how do ace inhibitors protect our kidneys the answer is that they caused decrease in circular matter or pressure which will decrease
The thickening of the government or basement membrane all right guys that’s everything i’ve got thank you so much for watching and i’ll see you guys later
Transcribed from video
Captopril, Lisinopril, and Enalapril – ACE Inhibitors Mechanism of Action and Side Effects By USMLE pass
