Glp-1 receptor agonists are i wouldn’t say a new class of medicines have been around for about 10 years now but a new class of medicines and they’re an increasingly popular class of medicines because they’re very effective at controlling a1c lowering your sugar which is the whole point of taking anti-diabetic medications but not only are they very effective at
Lowering a1c but they do something that most other anti-diabetic medications don’t do they help in weight loss and they’re very effective at that’s you most other anti-diabetic medications are either weight neutral but a great many of them actually cause people to gain weight so that’s why often they’re not very popular and that’s why these ones are becoming more
Popular because they are in many cases actually more effective than older medications but they also help in weight loss so after you’ve decided to take one of these medications these glp-1 receptor agonists the next question becomes well which one because there are a lot of choices out there we’re going to be talking about binary on and victoza in this video but
As of right now there is by duryea there’s victoza there’s byetta which was the first glp-1 there is trulicity there’s tans ‘i’m santa fe just came out with one it’s i’m not sure if it’s released yet but it will be shortly if it hasn’t been already novo which is the makers of victoza they’re coming out with a new one that it’s going to be at once weekly as well
So that’s seven right there and i believe there are two more in clinical trials and one of them actually i think might be a tablet all these currently are injectables no one’s figured out how to make it a tablet form of this but that will be about nine different medications that all do the same thing they’re all in the same class and when something’s in the same
Class that means they do the same thing so to give an example let’s say like a pickup truck a pickup truck is a class of cars they’re what defines a pickup truck is that it’s got four wheels got an engine and then it’s got space in the back hold stuff right the same class so all of these drugs are in the same class they do the same thing so after you’ve decided to
Take one of these the next question comes well which one so that’s what we’re going to do here when do comparisons and i’m not really going to go too much into the mechanism of action of these drugs there already other videos out there that explain exactly that so i’ll just leave that to them i mean if people really want me to talk about the mechanization i’ll do
That but i think if i’m not mistaken actually i’m really checked but it would be a someone wouldn’t be doing their job right one of these pharmaceutical companies if there wasn’t a video out there explaining exactly what it is i’ve seen one before so i’m assuming it’s on youtube but anyways we’re gonna get right down to it this first video we’re gonna do is we’re
Gonna compare by jury on which was the first once weekly for glp-1 and victoza which was the first once daily the first glp-1 as i mentioned before was byetta and that was a twice daily then came out through cosa and then came by durian and then a whole series of others started coming out so we’ll get to that comparison right now what’s often very difficult about
Comparing medicines is that often there are no head-to-head clinical studies but in this case we’re actually very fortunate because there was a head-to-head clinical trial done of victoza and by durian and that trial was called duration six and why it’s called duration six it’s because all pharmaceutical companies like to give their trials cool sounding names i
Don’t know why they do it they just do it so in this duration six they compared directly the once weekly binary on to the once daily victoza it was a twenty six week trial and what they compared there were several primary endpoints what they compared was its ability to lower a1c its sugar lowering ability and also compared the weight loss gained in each different
Medication and it also compared the side-effects did one have more side effects than the other we’ll start with the most important endpoint which is the lowering of a1c the whole point of this clinical study was to establish or to try to establish the non-inferiority of by tyrion to dick tosa because byetta was the first glp-1 that came out that was in 2005 i
Believe and in 2009 i think victoza came on victoza was a once-daily and byetta was the twice-daily so obviously because there was a lot more convenient koza also did a study comparing with toes it directly to byetta and they found that not only did it laure a1c better but they also lost more weight so basically victoza was winning in every single category it got
Better you won’t see results patients lost more weight and it was a once-daily versus it twice daily so that’s why victoza went off and became the market leader in this field because it was one of the earliest ones and it was a lot more convenient that was available at the time so then the makers of byetta took the same ingredient and they tried to reformulate it
To make it last longer make it more convenient and that’s how they came out with by durian by durian is the same active ingredient as by yetta but it’s a once-weekly instead of twice daily so a lot more convenient so the whole point of this study is they wanted to compare this new once-weekly version of byetta to victoza again see how it stood so in the first
Category the a1c they did the comparison i’ll show you the chart there and victoza definitely did better they both substantially lowered the a1c by 1.3 and 1.5 percent so they both did a very very good job but victoza definitely came out on top so it was not proven to be non inferior to victoza which basically means that victoza was better maybe not by a ton
But victoza definitely got the better results so the next category was weight loss and again victoza came out on top you can see the charts there it was about like two and a half to three and a half so quite a bit of difference there as well the the once-daily is the basically the daily injections of glp ones they tend to have greater weight loss than the once
Weeklies because there are quite a few once weekly is out and there are now quite a few once daily and that is just a trend that we see in general the once dailies definitely do a lot better in weight loss category and the final category was the side effects was there a significant difference in side effects did the once-weekly have more did it have less and this
Is whereby durian did a lot better than victoza so if you can see here the the difference mainly occurred in nausea vomiting and diarrhea and you can see there that victoza had a lot more reported side effects in this gastrointestinal sort of category the rest of them were more or less the same so those are not included it’s mainly in the gastrointestinal gi sort
Of side effects that there was a significant difference and as you can see there were a lot more reports of nausea vomiting and diarrhea and victoza and there were significantly more discontinuation as off of victoza because of this so by tirion was a lot better tolerated you can see as time goes on that they become more or less the same there might be a little
Bit more on victoza but it really it really levels out and that is just characteristic of this class of medications no matter which glp-1 it does take some time to get accustomed to the drug but after about six to eight weeks the side effects generally tend to subside away and they’re not really that noticeable but in the beginning you can see that the toes it
Has a lot more than by dura and so that’s a category that by durian winds in so in conclusion what is the difference between these two victoza definitely comes ahead as far as pure results and lowering a1c and in lowering weight but as far as convenience the once weekly injection or a dosage form of by durian might be something that someone might want to consider
As opposed to the once daily injection of dic tosa and also the side effect profile especially for someone who has never had glp-1 before the victoza might be a lot more difficult to tolerate than the by durian as you can see there from the side effects so i hope you found this helpful i will definitely do more of these because they’re a lot more drugs out there
Of this glp-1 class and there are plenty more coming out so i’ll definitely go over those maybe i’ll even make just one big long video that just compares everything that’s out so far but i hope you found this helpful and i’ll see you next time
Transcribed from video
Bydureon vs Victoza By Sons of Apollo
