Report on Lower Respiratory Tract System and drugs that is used to treat Lower Respiratory tract diseases
Good day everyone i am elika ullah from group 5 and i’m here to discuss with you the continuation of our report about lower respiratory system and some drugs that are used to treat low respiratory drug diseases so now my report is about another ellipta its generic name is umeclidine vilanterol but before we proceed let me give you an overview of what is copd
Copd or chronic obstructive pulmonary disease is a chronic inflammatory lung disease that causes obstructed air flow from the lungs its symptoms includes breathing difficulty cough mucous production and wheezing it’s typically caused by long-term exposure to irritating gases or particular matter most often from cigarette smoke people with copd are at increased
Risk of developing heart disease lung cancer and a variety of other conditions in copd amphisema and chronic bronchitis are the two most common conditions that contribute to copd these two conditions usually occur together and can vary in severity among individuals with copd when we say chronic bronchitis it is an inflammation of the lining of the bronchial
Tubes which carry air to and from the air sacs or alveoli of the lungs it is characterized by daily cough and mucus production so in the image at the right side you can see uh healthy and inflamed with excess mucus bronchioles next is emphysema it is a condition in which the alveoli at the end of the smallest air passage of the lungs are destroyed as a result
Of damaging exposure to cigarette smoke and other irritating gases and particulate matter although copd is a progressive disease that gets worse over time copd is treatable with proper management most people with copd can achieve good symptom control and quality of life as well as reduce risk of other associated conditions first let’s discuss the pharmacological
Class in which a noro ellipta belongs to pharmacological class anora ellipta contains two medications the omeglidinew and bilanterol the omaclidine neum belongs to a class of drugs known as the anticholinergics the anticholinergics are group of substances that blocks the action of neurotransmitter called acetylcholine at synapses in central and peripheral nervous
System anticholinergic symptoms includes dry mouth constipation urinary retention and increased heart rate vilanterol on the other hand belongs to the class of drugs known as long-acting beta-agonists or the law bus the long-acting beta agonists are taken on daily basis to relax the muscle lining the airways that carry air to the lungs this allows the tube to
Remain open both drugs are also known as bronchodilators when we see bronchodilators it dilates the bronchi and bronchioles decreasing resistance in the respiratory airway and increase the airflow to the lungs now let’s move on to the therapeutic indication of a noro ellipta therapeutic indication of anoro ellipta anora ellipta is combination anticholinergic
And long-acting beta-2 adrenergic agonist indicated for the long term once daily maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and emphysema anora ellipta is not indicated for the relief of acute bronchospasm or for the treatment of asthma this medication must be used regularly
To be effective it does not work right away and should not be used to relieve sudden shortness of breath if sudden breathing problems occur use your quick relief inhaler as prescribed umecladinone vilanterol or anoro ellipta is not approved to treat asthma people with asthma using long-acting inhale beta agonists such as valenterol without also using an inhaled
Corticosteroid may have an increased risk of serious breathing problems okay let’s move on to the mechanism of action of a neural ellipta mechanism of action there are two components of anural the lama and the laba the laba promotes the bronchodilation and the llama inhibits bronchocost constriction so the lava or the bilantaral it activates beta2 receptors and
Promotes bronchodilation dilemma on the other hand the omegladin pneum it inhibits binding of acetylcholine to muscarinic receptors it blocks the bronchoconstrictor effects of acetylcholine leading to bronchodilations the two components the lama and the laba could help maximize bronchodilation copd symptoms look different for everyone so consider if alama or
Alaba is right for your patients next is dosage information dosage information anoro ellipta should be administered as one inhalation once daily by the orally inhaled route only a narrow ellipta should be used at the same time every day do not use a noro ellipta more than one time every 24 hours no dosage adjustment is required for geriatric patients patients
With renal impairment or patients with moderate hepatic impairment next would be the clinical studies of anural ellipta clinical studies the safety and efficacy of anural ellipta were evaluated in a clinical development program that includes six dose ranging trials four lung function trials of six months duration there are two placebo-controlled and two active
Control two 12 week crossover trials and a 12 month long term safety trial the efficacy of anural ellipta is based primarily on the dose-ranging trials in 1908 subjects with copd or asthma and the two placebo-controlled confirmatory trials with additional support from two active controlled and two crossover trials in 5388 subjects with copd now let’s discuss
Some of the advanced improvement applied of this drug this is an example of advanced improvement applied in a narrow ellipta the gsk or glaxosmithkline study demonstrates superiority of a neural ellipta to stealth respimat in improving lung function in chronic obstructive pulmonary disease glaxosmithkline and innoviva today announced positive data from a study
Comparing a once daily long-acting muscarinic antagonist and a long-acting beta-agonist or lava fix those combinations anoro and stealth recipe mat for symptomatic patients with chronic obstructive pulmonary disease the primary endpoint for this eight-week open-label crossover study of 236 patients with copd was the demonstration of non-inferiority of umek bi or
The anora ellipta compared to stolto respimat in improving lung function as measured through forced expiratory volume in one second at eighth week this endpoint was met and furthermore anora ellipta demonstrated superiority to stealth respimat this data demonstrates that anuro provides superior long function improvements to the comparator stiotto raspimat lastly
We will discuss or give our conclusions about this drug and let us also review other informations about a neuro ellipta now we conclude that a neuro ellipta is used to control and prevent symptoms such as wheezing and shortness of breath caused by ongoing lung disease or copd which includes chronic bronchitis and emphysema this inhaler contains two medications the
Omegladineum and velanterol both drugs work by relaxing the muscles around the airways so that they open up and you can breathe more easily amecladynum belongs to a class of drugs known as anticholinergics and the bilanterol belongs to the class of drugs known as long-acting beta-agonists or the lavas both drugs are also known as bronchodilators this medication
Must be regularly used to be effective it doesn’t work right away and should not be used to relieve sudden shortness of breath if sudden breathing problems occur use your quick relief inhaler as prescribed omnic lady gnome valenterol or anoro ellipta is not approved to treat asthma people with asthma using long-acting inhaled beta agonists such as vilanterol
Without also using an inhaled corticosteroid may have increased risk of serious or sometimes fatal breathing problems let’s discuss some of drug interactions of anural ellipta caution should be exercised when considering the administration of anoro with ketoconazole and other known cyp 3a4 inhibitors as increased systemic exposure to bilantero and cardiovascular
Adverse effects may occur also beta blockers must be used with caution it may block bronchodilatory effects of beta agonies and produce severe bronchospasm anticoal energy may interact additively with common concomitantly used anticholinergic medications and that’s the end of our discussion thank you for listening
Transcribed from video
Anoro Ellipta for COPD By Elika Deanelle Ulep
