A synthetic substance. Normally seen as a white powder, it acts as a
Currently in all in doctor pharmacy program going to discuss about a drug amphetamine amphetamine is a synthetic substance rejected the stimulant of central nervous system first manufactured in 1880s by german chemist lucot they are derived from ephedra cynica which is native to china and mongolia the plant contains
Ferdinane and pseudoferdin which are natural alkaloids they belong from a family of any thylamine io pack name is n alpha methyl benzene methanomine isomers can be separated into two isomers livon phetamine and extreme phetamine as you see in the formula is cnh13 cnh13n it can be synthesized by two methods
Leucard method and fidel craft alkylation method in first we use phenyl acetone and region such as formic acid formamide to yield a racemic mixture of r and s enantiomer whereas in second method fiddlecraft alkylation of benzene by allyl chloride to yield beta chloropropyl benzene which is then reacted with ammonia
To produce sesame amphetamine now moving towards the pharmacokinetics of amphetamine absorption amphetamine is well observed in gut distribution and vitamins are distributed into body tissue especially in the brain and csf metabolism metabolized in liver by cyp2d6 amphetamine is eliminating where the urine now
Moving towards the mechanism when phetamine is transported by mono available transporters amphetamine inhibit vmat2 that store the dopamine in vesicles so more dopamine release and synapse amphetamine inhibit the uptake of dopamine through d80 phosphorylation it also act ac in mao inhibited that metabolite
The dopamine therapeutic effects adhd attention defect hyperactivity disorder is a condition is a chronic sleep disorder in which person can suddenly feel the attack of sleep obesity they work in the pain to reduce appetite and treat obesity adverse effect cns factor adverse effect of amphetamine usage include insomnia
Irritability weakness dizziness humor and hyperactive fluxes and cardiovascular effects amphetamine may cause acts on gi system causing anorexia nausea vomiting abdominal cramps now moving towards the toxicity of amphetamine toxicity refers to overdose of attack in bloodstream amphetamine toxicity should be
Suspected with diaphoresis hypertension and the patients having intestinal obstruction award also member mine 6.4 milligram per liter is the main lethal serum concentration anti-depressant increase the risk of heartbeat whereas amphetamine with bp drugs are sympathetic resulting in hypertension whereas if we take
Amphetamine with stomach acid drugs that decrease the stomach acids such as anti-acid and increase treatment of treatment by using amphetamine antipsychotics such as hydrolyzing and leviton are used as amphetamine drugs to treat the diseases i am really thankful to my colleagues for their contribution that’s all about
Amphetamine my aishaslam and myself sayathan thank you
Transcribed from video
All about AMPHETAMINE By EIATRIKOS
