Alfuzosin HCL and other alpha antagonists
So today we’re going to talk about alpha-1 selective focus okay alpha-1 selective oh curse so we have a number of products in this category so we have first be alpha loosing okay so alpha is awesome and then we have tamsulosin you and there are 13 so we want to focus on these three first okay so on this l fallen blockers and can be used to relax smooth muscle in
Benign prostatic hyperplasia okay so in bph benign prostatic hyperplasia already have this enlargement of the prostate plan okay so what you want to do is you want to relax the smooth muscle okay and so that you can increase in the you can you can increase the urinary flow rate okay and improve the obstructive symptoms because if your proceed is enlarged and then
You impinge on this area so you’re gonna have difficulty urinating so if you can improve this you can relax the smooth muscle here okay so you can allow the urine to flow smoothly you so we want to concentrate on firstly healthful reducing hydrochloride k4000 hydrochloride alfonso’s in hydrochloride so this drug and there are only tablets okay it’s it’s found
In tablets and also in modified release form okay also tablets so there are two types so there are the normal tablets or we have their modified release tablets you so let’s talk about the indications for what why do we give as position so as mentioned previously we give it to relax smooth muscle in benign prostatic hyperplasia can be p h so this is a condition
Affecting elderly men usually okay so they have problems in urinating so one of the treatment options is to if alpha blockers like l fuses in so what are the cautions okay cautions for in giving patients health or sourcing so we have to be aware that um alpha one selective alpha blockers they reduce blood pressure so patients who receive patients are already on
Anti hypertensive so we need to reduce the dose okay reduce dosage of alpha zosyn and we also have to be aware of if to be cautious in giving patients who are in the elderly category and also patients with hepatic and renal problems or impairment okay so you have happy to have liver and kidney problems then you have to be cautious so contraindications alpha blockers
Should be avoided in patients with history of postural hypotension okay postural hypotension so if patients have a drop in their blood pressure when changing posture then we have to hope try avoid giving them with drugs and also patients with micturition syncope okay make sure recién syncope because some patients they tend to blackout or faint okay when they meet
They have this and when they urinate so what are the adverse effects while the adverse effects or side effects of giving alpha dosing i don’t know right so um the side effects include drowsiness okay you become drowsy okay and then you have hypotension low blood pressure and so probably the drowsiness is because of this hypertension actually postural hypotension
And of course this can now see and then you have retention and that you can develop syncope okay you lose conscious consciousness and then you can become weak okay stl what we call st nia hey st nia some develop headaches and yes you might get gastrointestinal disturbances like nausea vomiting diarrhea constipation some people develop edema so this is the british
Spelling or you can have the american spelling below do and then blurred vision okay your vision vision becomes pet blue then you might have rhinitis okay slow motion in your nasal passage so can you might have erectile this you okay okay i’ve tachycardia probably as a reaction or action on the reaction of the body to hypotension so your body might compensate by
Forcing tachycardia and also you can have competitions and of course you might have hypersensitivity hypersensitivity reactions like crash practice ng dima et cetera so next we’re going to talk about your truck that is also like alpha sourcing which is dot sir the solution okay so dr. susan generally speaking it’s it’s very similar to it’s very similar to alpha
Sourcing except that i’m not aware of the drug having any any what we call modified release form okay so we only have giblets normal tablets so that stocks are sourcing and then again we have some time solution okay again it’s similar to quite very similar to al i’m also seen again it it the form is in test like at these two forms okay you can have tablets and also
You have absolute hey i’m not sure whether we have what if i release all that i’m aware of one good thing about or one advantage of some solution over alpha susan is that you can have you might give one steady um 400 micrograms tablet for patients okay so you can give a one table or one capsule so next is terrorizing the terror the scene also is quite similar to
Alpha loosing one difference probably is that you so you might develop so this is with the reducing so you might have the weight gain okay you might increase you have been increasing your weight okay and then you might have decreased libido okay amigo and some people have the back pain okay so that can reduce in otherwise you have also tablets only for for the for
Terror so sigma k and and when it comes to brand names okay for terror also seen there is a quite a famous brand which is hi three iraqi terrors are seen there is a brand called hi tree so you don’t have to memorize this but just in case you noticed some people are on this drug i train so you know that this is a crop that is an alpha blocker that is usually used
To treat benign prostatic hyperplasia so i think that’s all for now okay we will continue in the next video okay thank you
Transcribed from video
Alfuzosin HCL and Terazosin By Pharmacology RCMP
