Adrenergic antagonists 1
So welcome back we’re going to talk about um a dream is you can’t agonist ok adrenergic antagonist so they are croc step act and holistically on the adrenergic receptors again the alpha and beta receptors so they will antagonize the effects of the antagonist so the effects of the sympathetic nervous system can be inhibited either by one of three ways okay number
One is by reducing sympathetic outflow from the brain here reducing sympathetic outflow from the brain so that’s one way of inhibiting the effects of sympathetic nervous system number two is suppressing release of norepinephrine from the terminals okay if you suppress the release of norepinephrine you press the release of non adrenaline from the terminals so you
Can inhibit the effects of the sympathetic nervous system so the third way is by blocking whose synaptic receptors in blocking the receptors so this is the muslim the most obvious one that is to block this post synaptic receptors if you can block the postsynaptic receptors then you can block or you can inhibit you can stop the effects of the sympathetic nervous
System so there are three three ways reducing sympathetic outflow from the brain reducing sympathetic stimulation from the brain number two suppressing the release of norepinephrine from the terminals or by blocking stopping inhibiting the receptors post synaptic lee okay so a green ticket agnes they reduce the effectiveness of sympathetic nervous to malaysian and
Also the effects of exogenously administered agonist okay such as isoproterenol okay so that’s how the yet they reduce effective the effectiveness of sympathetic nervous to malaysian and also the effects of exogenously understand administered agonist so logically they are divided into two one is the one that blocks the floor receptor so they are known as the alpha
Receptor blockers or the alpha receptor antagonist secondly you have the better receptor blockers or the penta receptor antagonist so first we have the central focus alpha two agonist reduce sympathetic nerve activity okay alpha-2 agonist reduce sympathetic nerve activity and it’s used to treat hypertension okay alpha 2 receptor activation blocks simplex they all
Flow from the brain and also the release of norepinephrine from nerve terminals okay so these drugs they even though their agony is actually but via action is like an antagonist case audio effects are considered and talk antagonistic to the effects of alpha 2 so the block sympathetic output from the brain and also block the release of norepinephrine from the nerve
Terminals it we get this one okay this is number one producer petty surprise the odd flow from the brain so press release of norepinephrine from terminal so it fulfills these two criteria it doesn’t need to feel fulfilled all criteria it can just fulfill one of the criteria or two all but but or this rock with alpha-2 agonist k v actually somehow they reduce the
Severity or flow from the brain and also suppress the release of norepinephrine from terminals so such drugs include low needing so if you still remember that how many mention it in in the elf in the religion agonist talk so it’s coming back here only need one advance once the scene okay and then we have is a needy it is a need in which is used for treatment of
Spasticity spasticity okay for example for cerebral palsy patients was we are in pain okay so they need to be given something on your spasticity so example is t to sanity so there are many drugs actually they can have else file blocking properties okay they have alpha-adrenergic blocking properties so alpha adrenergic antagonistic effects including antipsychotics
Okay and psychotics many drugs that are used to treat type attic symptoms of schizophrenia bipolar and other diseases are the conditions they you will have k they will they will have effects of alpha blocking effects okay so mostly what it causes vasodilatation making best suit annotations or when they have fast food allocation okay it will eventually cause the
Reduction in the blood pressure in reduction in the blood pressure so the adverse effects of these drugs include postural hypotension postural hypotension okay so the blood pressure goes down it uses if you change position from lying down to i’m standing so that’s postural hypotension it’s hypotension it’s a lowering your blood pressure caused by a change in
Your posture okay in simple terms and also reflects tachycardia he causes a reflex tachycardia so it’s we are expecting it to reduce a blow this the highbreed but instead it causes a reflex in the heart rate increase because of the blocking effects and then the relaxation of smooth muscle in the bloody neck and prostate helps make the urine flow better in patients
With benign prostatic hyperplasia okay so this this kind of drugs okay for example f elf who’s awesome can be used to treat benign prostatic hyperplasia which usually happens in the elderly and in elderly meals okay so this is a loser scene okay that is used to um treat benign prostatic hyperplasia and then we have tamsulosin and c low dose in okay tamsulosin and
Zero racine that i used they are specific for alpha 1 e alpha 1 e so this is the bladder okay they the urine flow here the retro the prostatic urethra and this is the prostate gland in the prostate line so in v ph in benign prostatic hyperplasia you have the prostate and logic okay so in order to relax this area okay the bloody neck and prostate okay so you want
To relax muscles here so that you can have a nice flow out flow theory so you can give some solution and see low dose in okay i’m solution n 0 to see so these are alpha adrenergic focus and tamsulosin is specific for alpha 1 e and so is saludos in case drugs are specific for alpha 1 ii receptors so showing quite a similar pictures and we have shown in the previous
Talk so we have phentolamine and to allow salim that text almost similarly on the alpha-1 and alpha-2 and then we have alpha two antagonists which is your him beam which previously had no clinical role i’m not sure it has any clinical role nowadays but previously it had had no clinical role okay there’s nothing you don’t use your him being in in patients to treat
Certain conditions okay i’m gonna have a doc simmons i’m in here which is somewhere i’m toward cell phone one okay and then we have two pure element blockers or soc processing tiaras lucy knox also seen and three mothers in hey so these rocks have fewer adverse effects due to its specificity okay but these drugs are very specific okay it has fewer adverse effects
So beta blockers beta one is mainly on the heart okay as we have mentioned previously in beta 2 x on the smooth muscle of the respiratory tract the uterus and also the blood vessels okay so that’s why beta 2 x it acts upon the in the urine respiratory tract uterus and blood vessels okay the smooth muscles and these miri’s so chronic administration of beta-blockers
Will cost reduction in blood pressure okay and they are used k beta blockers are used to treat arrhythmias abnormal rhythms of the heart in china okay hypertension which is high blood pressure hyperthyroidism increased thyroid hormones due to many conditions lymphoma increase your intraocular pressure okay and migraines okay anxiety and beta blockers should be used
Cautiously in diabetics okay cautiously diabetics diabetics so simple because sympathetic stimulation k or beta receptors needs to glycogenolysis gluconeogenesis and lipolysis okay you so binturong selective blockers if they are selective for greater light instead we know that the arc i do selective okay it’s it’s more it’s more prone to act in the heart it has
More action in the heart so metal and selectively includes with a most addictive drugs include is virtual all eternal all bent up soul all be so prolonged and smaller and mental prolong okay so this one’s a better one selective okay s brutal all afternoon wall items halal bisoprolol and metoprolol okay try to remember it is attainable in miss oprah lon and also
Metoprolol cave is a very famous drugs and then the non selective ones a non selective ones we have propranolol cartier all level below wall now the law pen bhutto la fin de la and tim okay so these are non-selective beta one blockers to some beta blockers have intrinsic suppressor magnetic activity so meaning that they have a partial agonist they can cause they
Can exert partial agonist effects okay so they can be considered as partial agonist with high affinity for the researchers this picture has somehow it’s not story heated to the um two better work this okay it’s just a design suggested by the artificial intelligent whole point so mixed lol sorry beta blockers we have labetalol okay and we have covered it all mindy –
Laboratory is also often listed as a beta 1 it is a beta blocker and it has with some an alpha blocking activity in a bit alone i’ll show you i shoot this in the picture you all sort of the self okay so we didn’t show the picture the diagram so this is this drug is non-selective beta receptor okay but it’s specific for alpha one travel you all is non-selective
Beta blocker and it has no intrinsic simple magnetic activity and it also is a bit alpha is an alpha one blocker okay a very long so in general you have to remember at least that elaborate at all and avenue all are mixed alpha and beta blockers kavia all makes alpha and beta blockers so we’ll continue in another video thank you
Transcribed from video
Adrenergic antagonists 1 By Pharmacology RCMP
